BREAKING! Study Finds High Expression Of ACE2 Receptors On Keratinocytes And Warns That Human Skin Could Be A Potential Target For SARS-CoV-2!
Our understanding and data about the SARS-CoV-2 and the COVID-19 disease is evolving day by day but we are still lagging behind the novel coronavirus as the virus itself is evolving and coming up with new variants that behave differently and also exhibit different pathogenesis and affects different human cellular pathways and also reacts differently with those pathways.
To make matters worse, there is a lot that we do not know about the human body!
A study by researchers from Shandong First Medical University & Shandong Academy of Medical Sciences-China has revealed that the human skin
has a high expression of ACE2 receptors (One of the main the receptors that the SARS-CoV-2 virus enters the human cells) on keratinocytes and warn that the human skin can also be target for the SARS-CoV-2 coronavirus especially the emerging potent variants. (There is still a lot we do not know about the emerging variants and stupid virologists or ‘experts’ should think twice before they discount anything!)
The study was published in a peer reviewed journal By Elsevier: Journal Of Investigative Dermatology. https://www.jidonline.org/article/S0022-202X(20)31602-X/fulltext
Human skin as a functional physical and immune barrier could prevent the invasion of foreign pathogens, including bacteria, fungi, and viruses. Once the skin barrier is disrupted however, humans have an increased susceptibility to microbial colonization and infections. https://pubmed.ncbi.nlm.nih.gov/21682749
Cutaneous manifestations of SARS-CoV-2 infection were reported in 20.4% (18/88) patients and were found to be similar with other viral skin infections. https://pubmed.ncbi.nlm.nih.gov/32215952/
The study team systematically analyzed ACE2
expression and ACE2
-positive cell composition in skin tissues and found a high expression of ACE2
in keratinocytes, especially in differentiating keratinocytes and basal cells, suggesting that skin might be a potential target of SARS-CoV-2. Eczematoid dermatitis was induced by long-term wearing of protective clothing and contacting disinfectant, which might be a crucial factor to cause percutaneous infection in patients with coronavirus disease 2019 and medical personnel. https://pubmed.ncbi.nlm.nih.gov/32170800/
Healthcare workers, especially those who worked at the first line, and patients with dermatosis with skin barrier dysfunction may be risk populations for percutaneous infection. In addition, keratinocytes may become infected through hematogenous viral spreading following inoculation of the upper airways. https://pubmed.ncbi.nlm.nih.gov/32213337/
The study findings provided a viewpoint to the routes of SARS-CoV-2 transmission, which to our knowledge were not reported previously.
The study team concluded that the high expression of <
;em>ACE2 on keratinocytes in human skin indicated that percutaneous transmission might be a potential risk route for SARS-CoV-2 infection, especially in conditions of skin barrier dysfunction. Also, keratinocytes are potential target cells for the viral infection when a patient is in a state of viremia. Currently, SARS-CoV-2 has been pandemic worldwide. The potential risk routes by which SARS-CoV-2 infects keratinocytes and cutaneous manifestations of SARS-CoV-2 infection should be brought to our attention as well.
It should be noted that in another study it was shown that sweat glands were found to be infected with SARS-CoV-2 virus! That study was published in the peer reviewed journal: Nature Cell Discovery. https://www.nature.com/articles/s41421-020-00229-y
Studies have also shown that he SARS-CoV-2 virus can survive on human skin for up to 9 hours! https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1517/5917611
We will also be covering another study that is soon to be published that has been in the works for the last 9 months also with regards to the Skin and SARS-CoV-2 coronavirus by another research team in Shanghai.
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