Thailand Medical News - For All The Latest Breaking Medical News, Health News, Research News, COVID-19 News, Outbreak News, Dengue News, Glaucoma News, Diabetes News, Herb News, Phytochemical News, Heart And Cardiology News, Epigenetic News, Cancer News,

BREAKING NEWS
Source: COVID-19 Drugs  Aug 21, 2021  2 years, 7 months, 3 weeks, 6 days, 13 hours, 17 minutes ago

BREAKING! American and German Study Shows That Heartburn Drug Famotidine With Aspirin Prevents COVID-19 Disease Severity and Mortality

BREAKING! American and German Study Shows That Heartburn Drug Famotidine With Aspirin Prevents COVID-19 Disease Severity and Mortality
Source: COVID-19 Drugs  Aug 21, 2021  2 years, 7 months, 3 weeks, 6 days, 13 hours, 17 minutes ago
COVID-19 Drugs: A detailed meta-analytical study by researchers from the University of Virginia-USA, Humboldt-Universität zu Berlin-Germany,  Freie Universität-Germany and  Berlin Institute of Health, of previous research findings including clinical trials has revealed that the heartburn drug famotidine used alongside Aspirin has the potential to prevent disease severity and mortality in those infected with the COVID-19 disease.

The study showed real-world evidence for improved outcomes with Histamine H2 receptor antagonists (H2RAs) such as famotidine and aspirin in more than 22,560 COVID-19 patients.
 
A dense web of functional linkages exists between histamine and H2RAs, on the one hand, and disparate physiological pathways on the other hand. These downstream signaling pathways include gastrointestinal systems (acid reduction) as well as the dysregulated inflammatory cascades (cytokine storm) that likely underlie much of the pathophysiology of COVID-19.The mechanistic basis of a putative role of famotidine in COVID-19 likely involves its roles as an H2RA versus, for instance, direct binding to the viral protease 3CLpro (and resultant inhibition), as had been originally suspected from molecular docking studies.
 
The study team says that famotidine is useful in treating COVID-19 because of the capacity of H2RAs to attenuate the pro-inflammatory pathways that become dysregulated upon infection (cytokine storms activate pro-fibrotic pathways; lung damage eventually results). Thus, a role for famotidine in COVID-19 may stem from cellular mechanisms and signaling pathways quite unrelated to its classic therapeutic role in gastroenterology that, in turn, is an important lesson as regards drug repurposing (from a systems pharmacology perspective), targeted therapeutics, and the general idea of a COVID-19 ‘disease map’.
 
The study findings were published as a correspondence in the peer reviewed journal: Signal Transduction & Targeted Therapy (from the Nature publishing group). https://www.nature.com/articles/s41392-021-00689-y
 
Thailand Medical News had been reporting about the potential use of famotidine to treat COVID-19 since May 2020.
https://www.thailandmedical.news/news/covid-19-drugs-study-shows-common-and-cheap-heartburn-drug-famotidine-improves-outcomes-of-hospitalized-covid-19-patients
 
https://www.thailandmedical.news/news/breaking-studies-show-famotidine,-a-common-indigestion-drug-could-help-in-mild-to-moderate-cases-of-covid-19

https://www.thailandmedical.news/news/breaking-covid-19-treatments-second-observational-study-shows-famotidine-associated-with-better-outcomes-for-hospitalized-covid-19-patients

 
//www.thailandmedical.news/news/covid-19-treatments-study-shows-using-dual-antihistamines-such-as-cetirizine-and-famotidine-helps-pulmonary-symptoms-in-covid-19-patients">https://www.thailandmedical.news/news/covid-19-treatments-study-shows-using-dual-antihistamines-such-as-cetirizine-and-famotidine-helps-pulmonary-symptoms-in-covid-19-patients
 
Duri