Thailand Medical News - For All The Latest Breaking Medical News, Health News, Research News, COVID-19 News, Outbreak News, Dengue News, Glaucoma News, Diabetes News, Herb News, Phytochemical News, Heart And Cardiology News, Epigenetic News, Cancer News,

BREAKING NEWS
Source: Thailand Medical News  Feb 04, 2020  4 years, 2 months, 2 weeks, 6 hours, 16 minutes ago

Researchers Identify Link Between Chronic Kidney Disease And Heart Failure

Researchers Identify Link Between Chronic Kidney Disease And Heart Failure
Source: Thailand Medical News  Feb 04, 2020  4 years, 2 months, 2 weeks, 6 hours, 16 minutes ago
Individuals with chronic kidney disease have a higher risk for heart disease and heart-disease death. Now, for the first time in humans, research led by Dr Navkaranbir Bajaj, M.D., of the University of Alabama at Birmingham, has identified a pathological change that appears to link kidney disease to progressive heart disease.



The new discovery offers a potential treatment target, which could have wide benefit because 14 percent of the U.S. adult population has chronic kidney disease. The research is published in the journal Circulation, with Dr Bajaj, a UAB Assistant Professor in the Division of Cardiovascular Disease, Department of Medicine and Department of Radiology as first author.
 
Dr Bajaj told Thailand Medical News, "I am now collaborating with other UAB researchers to figure out how we can target therapeutics to help these patients."
 
Coronary microvascular dysfunction, or CMD is the identified pathological change say Dr Bajaj along with  research colleagues at Harvard Medical School. CMD is decreased blood flow in the small blood vessels inside the heart muscle that provide oxygen and fuel to feed the pumping heart.
 
Normally in healthy hearts, visualized postmortem, these blood vessels look like a tight filigree network that fills the heart muscle tissue. A diseased postmortem heart has lost much of this network. In living patients, however, those small blood vessels inside the heart muscle cannot be visualized; blood flow scans of living patients visualize only the larger, exterior coronary arteries. So Dr Bajaj and colleagues needed an indirect way to gauge CMD.
 
That new measure is coronary flow reserve, or CFR, which Dr Bajaj and colleagues measured via positron emission tomography. CFR is the maximum increase in blood flow through the coronary arteries above the normal resting volume. Dr Bajaj, a cardiologist who trained at UAB, did his advanced imaging fellowship at Brigham and Women's Hospital in Boston, before returning to UAB in 2018.
 
It was observed that In a longitudinal study of 352 patients with chronic kidney disease, all with healthy heart function as measured by ejection fraction and none with signs of overt coronary artery disease, the researchers measured CFR and also measured signs of subclinical heart dysfunction via deformation analysis with echocardiograms. The patients were then followed a median of 4.4 years for major adverse cardiac events. A total of 108 patients had such major events, including death and hospitalization for non-fatal heart attack or heart failure.
 
The medical researchers found that CMD was a significant predictor of abnormal mechanics of the left ventricle, the heart's major pumping chamber and a significant predictor of clinical risk of adverse cardiovascular outcomes.
 
A new statistical model called mediation analys