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Source: COVID-19 Drug Research  Apr 11, 2020  4 years, 6 days, 17 hours, 52 minutes ago

MUST READ! COVID-19 Drug Research: Ivermectin Might Emerge As One Of The Most Suitable Drug Candidates For COVID-19

MUST READ! COVID-19 Drug Research: Ivermectin Might Emerge As One Of The Most Suitable Drug Candidates For COVID-19
Source: COVID-19 Drug Research  Apr 11, 2020  4 years, 6 days, 17 hours, 52 minutes ago
COVID-19 Drug Research: For the past week, lots of media was abuzz about the results of an in vitro study by Australian researchers involving Ivermectin, a drug used to treat parasitic infections.


 
A single dose anti-parasitic drug was found to be able to stop the SARS-CoV-2 coronavirus from replicating in cells within 48 hours, according to findings from the vitro studies by Monash University’s Biomedicine Discovery Institute (BDI), working with the Peter Doherty Institute of Infection and Immunity.
 
Dr Kylie Wagstaff from Monash Biomedicine Discovery Institute’s commented, “We found that even a single dose could essentially remove all viral RNA by 48 hours and that even at 24 hours there was a really significant reduction in it.”
 
The study was published in the journal On Antiviral Research. https://doi.org/10.1016/j.antiviral.2020.104787
 
We at Thailand Medical News initially decided to hold off covering the development till more supporting evidence appeared, however it seems that there are more data that supports it usage but for whatever reasons, entities involved are holding off making any official announcements.
 
The US FDA approved drug, Ivermectin, has been used widely used for decades. It was introduced as a veterinary drug in the 1970s and subsequently was used to treat humans for a variety of parasitic infections and also head lice, scabies etc.
 
In the vitro study, the medical researchers infected cells with SARS-CoV-2, then exposed them to ivermectin. "We showed that a single dose of ivermectin could kill COVID-19 in a petri dish within 48 hours, indicating potent antiviral activity," says study co-author Dr  David Jans, PhD, a Professor of Biochemistry and molecular biology at Monash University in Melbourne.
 
While the Australian researchers warned that it was still too early till studies were conducted in humans, which the same group has already started already doing so, it emerged that there were groups already conducting human trials in London and Maryland, US under special circumstances and that there were already animal studies done in early March by the same group in Maryland, US that did not want to publish the studies just yet.
 
Dr Jans said, "The main way ivermectin works is to target a key molecule of our cells that helps the virus to proliferate. By stopping this, the virus replicates more slowly, and so our immune system has a better chance to mount the antiviral response and kill the virus. Giving this or any antiviral drug early is thought to give the body the best chance of beating infection.”
 
In past studies, the researchers say, the drug has been shown to work against dengue fever and to limit infections similar to COVID-19, such as the West Nile virus.
 
Dr Jans added that the drug is "safe at relatively high doses”.
 
However, Thailand Medical News has come across reports that say the drug can be neurotoxic at doses above 35mg.
 
; “This vitro study certainly piqued our interest,” says Dr Jill Weatherhead, MD, an assistant professor of adult and pediatric infectious diseases at Baylor College of Medicine in Houston. Her clinic uses the medicine to treat intestinal parasites found in international travelers or immigrants.
 
The critical caveat, says Dr Weatherhead, who reviewed the study but was not involved in the research, is that it was done in a lab. But "at this point, any lead we have should be investigated," she says. "What we really need to know is, could you translate that concentration of the drug used in the lab study into human studies and have it be safe?" (Dr Wethearhead at the time of making the comment was not aware that human clinical trials