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Source: Thailand Medical News  Feb 23, 2020  1 month ago
Latest On Coronavirus Drug Research: Chloroquine Another Potential Drug Candidate
Latest On Coronavirus Drug Research: Chloroquine Another Potential Drug Candidate
Source: Thailand Medical News  Feb 23, 2020  1 month ago
Latest coronavirus drug research indicates that based on early results from clinical trials by Chinese researchers, Chloroquine Phosphate, an antimalarial drug, has a certain curative effects on the novel coronavirus disease (COVID-19).


China National Center for Biotechnology Development deputy head Dr Sun Yanrong said that chloroquine, an anti-malarial medication, was selected after several screening rounds of thousands of existing drugs.
 
The drug is undergoing clinical trials in more than ten hospitals in Beijing, Guangdong province, and Hunan province.
 
Dr Su said that chloroquine phosphate, which has been used for more than 70 years, was selected from based on earlier studies. (https://doi.org/10.1038/s41422-020-0282-0)
 
Considering that it is already an approved drug, it can easily be approved for repurposing to treat the coronavirus if further research trials show its efficacy without any side effects.
 
Coronavirus infected patients treated with chloroquine demonstrated a better drop in fever, improvement of lung CT images, and required a shorter time to recover compared to parallel groups.
 
The percentage of patients with negative viral nucleic acid tests after treatment was also higher with the anti-malarial drug.
 
Chloroquine has so far showed no obvious serious adverse reactions in the more than 100 participants in the trials.
 
Data from the drug’s studies showed ‘certain curative effect’ with ‘fairly good efficacy’.
 
The China National Center for Biotechnology Development head Dr Zhang Xinmin said that chloroquine is one of the three drugs that have a promising profile against the new SARS-CoV-2 coronavirus that causes the Covid-19 disease.

The remaining two drugs are anti-flu medicine favipiravir (https://www.thailandmedical.news/news/china-approves-favipiravir-avigan--as-an-experimental-drug-to-treat-coronavirus)  and Gilead’s investigational anti-viral candidate remdesivir.( https://www.thailandmedical.news/news/gilead%E2%80%99s-remdesivir-may-turn-out-to-be-a-saviour-in-the-battle-against-the-coronavirus-as-long-as-antiviral-resistance-does-not-occur-)
 
Favipiravir is currently in a 70-patient trial in Shenzhen, Guangdong province, while remdesivir is under evaluation at more than ten medical institutions in Wuhan.
 
The Chinese medical experts have "unanimously" suggested that the drug chloroquine be included in the next version of the treatment guidelines and applied in wider clinical trials as soon as possible.
 
Past research involving vitro experiments showed that it can block virus infections by changing the acidity and basicity value inside the cell and interfering receptors of the SARS coronavirus.
 
The drug also demonstrates immune-modulating activity, which may enhance its antiviral effect in vivo and is widely distributed in the whole body, including the lungs, after oral administration.
 
However many medical researchers, pharmaceutical experts and virologist are warning that while vaccine and drug research is being conducted, careful attention should be paid to watch for coronavirus evolution  in patients for the emergence of novel mutations, as certain mutations could render all efforts futile.( https://www.thailandmedical.news/news/breaking-news-:-new-studies-emerging-that-confirms-the-coronavirus-is-mutating-and-becoming-more-virulent)
 
For more on the latest of coronavirus drug research or vaccine developments, keep checking at : https://www.thailandmedical.news/articles/coronavirus
 

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