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Source: Latest COVID-19 Conspiracy Theory  Aug 16, 2020  3 years, 7 months, 4 weeks, 1 day, 21 hours, 5 minutes ago

Latest COVID-19 Theory That SARS-CoV-2 Had Been Subjected To Serial Passaging Enhancement Processes-Fake News And Misinformation Or Plausible?

Latest COVID-19 Theory That SARS-CoV-2 Had Been Subjected To Serial Passaging Enhancement Processes-Fake News And Misinformation Or Plausible?
Source: Latest COVID-19 Conspiracy Theory  Aug 16, 2020  3 years, 7 months, 4 weeks, 1 day, 21 hours, 5 minutes ago
Latest COVID-19 Theory: We at Thailand Medical News typically avoid any kind unsubstantiated claims or theories and ‘cooked up’ studies and in fact we have been amused at the quality of misinformation that there is on the internet and some even perpetrated by health organizations, regulatory bodies, pharma giants, medical researchers and governments  using phenomenal resources and monies to even rope in the American media and social media platforms in elaborate scams to make claims that toxic drugs such as chloroquine, hydroxychloriquine, remdesivir, tocilizumab and favipiravir etc is able to treat COVID-19! ( we are not going to go into details there are tons of real credible studies and materials on our site and on other online sites that explains why.)


 
Then off course there are the stupid claims that 5G is causing the COVID-19 pandemic or that some African voodoo doctor has created a cure for COVID-19 or worse, that it some conspiracy by the U.S. Democrats and business elites to control people or about Bill Gates’ fetish with implanting humans with chips using the vaccine to boost sales of his upcoming ‘Windows 19.’
 
However there is a new theory that is abuzz on numerous online media that is proving to be interesting but needs more evidence to substantiate the claims https://www.independentsciencenews.org/commentaries/a-proposed-origin-for-sars-cov-2-and-the-covid-19-pandemic/ and that theory is coupled with  virus enhancing process known as ‘serial passaging.
 
This new theory is that the SARS-CoV-2 coronavirus was really leaked from the Wuhan laboratory in China but that prior to being leaked, the SARCoV-2 coronavirus went through not a straight forward technical genetically manipulation process but rather a method known as “serial passaging’ which allows the virus to go through a process that mimics natural evolution but is actually a carefully laboratory acceleration process of enhancing viruses.
 
This new theory is gaining traction due to new emerging materials. The new data also show that the coronavirus actually jumped directly from the bats to humans without any intermediate animals except for the Chinese researchers at that laboratory who were conducting experiments on that virus.
 
The new theory starts with fact that the Bat coronavirus  BtCoV/4991 or RaTG13 coronaviruses are the closest relative of the SARS-CoV-2(almost identical in terms of genetic material to the tune of about 96.00 %) https://www.nature.com/articles/s41564-020-0771-4 and https://www.nature.com/articles/s41586-020-2012-7
 
In late April 2012 there was a reported incidence that six miners at the Mojiang Mine fell ill with unknown pneumonia. The mine was infested with horseshoe bats that carried the RaTG13 Bat coronavirus.
 
It was reported that these miners were brought to Kunming University Hospital in Yunnan, which is about 250 km from the mine. Their symptoms include dry cough (all patients), sputum (all), high fever (all), difficulty breathing (5), myalgia (5), low blood oxygen levels (4), headaches (3), and blood clots (2). Treatments used were steroids (all), antivirals (5), ventilation (3), and blood thinners (2). And half of the miners (3) died in the end.
 
It was deemed that the miners had contracted a mysterious illness. (Wu et al., 2014). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036791/
 
The incidence was described in a Chinese Master’s thesis written in 2013 by a doctor who supervised their treatment.  https://www.documentcloud.org/documents/6981198-Analysis-of-Six-Patients-With-Unknown-Viruses.html
 
Interesting, it was recorded that bio samples (at least blood and thymus tissues) from the miners were sent to the Wuhan Institute of Virology to determine the causative agent. The conclusion made was that “the unknown virus lead to severe pneumonia could be the SARS-like-CoV from the Chinese rufous horseshoe bat,” wrote the authors. Hence the miners could have had a coronavirus infection.
 
Also in that same year, Dr ZhengLi Shi, director of the Center for Emerging Infectious Diseases at the Wuhan Institute of Virology, led a surveillance study at the same Mojiang Mine. Her team collected fecal swabs from 276 bats. Using genetic sequencing, they detected nine coronaviruses species, of which six were never classified and one was RaTG13. (note that that RaTG13 is a bat sarbecovirus that is 96% identical to SARS-CoV-2). https://www.nature.com/articles/s41586-020-2012-7
 
It was said that some of these coronavirus species had likely infected the miners, although no comparative studies have confirmed this. Such events are not at all new as bat-to-human spillovers of viruses had occurred before. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178078/
 
Although RaTG13 is the closest relative of SARS-CoV-2, a 4% genomic difference is still too vast, which requires at least 20–50 years of evolution. Hence, an intermediate host is likely involved, as was the case of SARS and MERS, because coronavirus evolution rate speeds up in a different species. https://www.scimex.org/newsfeed/expert-reaction-did-covid-19-come-from-a-lab-in-wuhan
 
It is also assumed that the RaTG13 coronavirus may have may have evolved and mutated slightly while being in the miners’s bodies as coronaviruses normally evolved or mutate each time they are in a new host.
 
Note that samples (blood and thymus tissues) from the miners were sent to the Wuhan Institute of Virology for research purposes. As their labs were under construction at the time of sample collection, virologists may have stored these samples and only begun experimentations in 20