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BREAKING NEWS
Source: Diabetes  Jun 17, 2020  2 months ago
Diabetes: Study Shows Continuous Glucose Monitoring (CGM) Medical Devices Helps Reduce Hypoglycemia In Elderly With Type 1 Diabetes
Diabetes: Study Shows Continuous Glucose Monitoring (CGM) Medical Devices Helps Reduce Hypoglycemia In Elderly With Type 1 Diabetes
Source: Diabetes  Jun 17, 2020  2 months ago
Diabetes: The elderly with type 1 diabetes (T1D) is a growing but under-studied population that is prone to hypoglycemia, particularly when diabetes is longstanding. Unknown to many, hypoglycemia can cause altered mental status and sometimes seizure or loss of consciousness, which can prove fatal.


According to this six-month, multi-site clinical study trial called the Wireless Innovation for Seniors with Diabetes Mellitus (WISDM) , older adults who use continuous glucose monitoring (CGM) devices can significantly reduce the occurrence of hypoglycemia and severe hypoglycemic events while also reducing hemoglobin A1c.
 
The research findings from the trial have been published by the Journal of the American Medical Association (JAMA). https://jamanetwork.com/journals/jama/article-abstract/2767159
 
The main purpose of the study was to determine if the use of CGM can reduce hypoglycemia among older adults with type 1 diabetes (T1D). A CGM device continuously measures blood sugar and provides real-time observation of glucose levels, trend direction, and alarms for when glucose drops to low levels or increases to high levels.
 
University of North Carolina’s principal investigator Dr Laura Young, MD, Ph.D., Associate Professor of Medicine in the division of endocrinology and metabolism at the UNC School of Medicine told Thailand Medical News,
"Reducing hypoglycemia is an important aspect of management of T1D in older adults, many of whom have difficultly recognizing symptoms of hypoglycemia or cognitive impairment.”
 
The clinical research was a randomized, controlled trial involving 203 men and women over the age of 60 at 22 clinical centers, including UNC-Chapel Hill. About half of participants were receiving insulin via an insulin pump and the other half used multiple daily injections of insulin. Half of participants were randomly assigned to a group using a Dexcom CGM device, and the other half to a control group using the standard finger-stick method with test strips for blood glucose monitoring.
 
The clinical research  found that the amount of time glucose levels were in a hypoglycemia range (< 70 mg/dL) was reduced from 73 minutes per day at the start of the study to 39 minutes per day in the group using CGM for a 6-month period; whereas for people in the control group, their average minutes per day in hypoglycemia was 68 minutes per day at the start of the study and 70 minutes per day over the six-month study period.
 
Some other major findings were:
 
1. Continuous Glucose Monitoring or CGM users were far less likely to have a severe hypoglycemic event compared to the control group using blood glucose meter checks; 10 participants in the control group had a severe hypoglycemic event compared with only one participant in the CGM group. Five of the 10 severe hypoglycemic events reported in the control group involved seizure or loss of consciousness, which did not occur in the one CGM group event.
 
2. It was observed that reducing hypoglycemia did not come at the cost of worsening overall glucose control. The average hemoglobin A1c (HbA1c, an estimate of blood glucose control over a 3-month period) for the CGM group improved from 7.6% at the start of the study to 7.2% at 6-months. The control group HbA1c was 7.5% at the start of the study and 7.4% at 6-months. The American Diabetes Association recommends an HbA1c target of < 7.0% for adults, but with less stringent targets for older adults prone to hypoglycemia.
 
3. Fluctuations or very low or very high blood glucose episodes can be dangerous. Regular CGM use increased the amount of time in target range (glucose levels of 70 mg/dL to 180 mg/dL) by more than two hours a day.
 
It was also discovered that 81% of study participants were still using the CGM devices seven days per week at six months. These results are important because they demonstrate CGM can be used effectively in an older adult population to reduce hypoglycemia, as well as improve overall glucose control. Because hypoglycemia can lead to serious complications, including hospitalization and death, the reduction in severe hypoglycemic events could have important public health implications.
 
Dr Young said, "For too long, the older population with diabetes has suffered from not-so-benign neglect from the medical community. Despite the high prevalence of diabetes and its complications in this age group, very few studies have addressed the potential utility of new technologies in this population. In part, this may be due to the mistaken belief that older adults can't manage or benefit from advanced technologies.”
 
She further added, “Our study shows quite the opposite. Not only does CGM improve safety in older adults, it actually improves overall glycemic control. Moreover, the overwhelming majority of patients in our study used CGM most days for the entire duration of the study, demonstrating a high level of comfort with the technology in this population."
 
The treatment impact on reducing hypoglycemia at six months was present on those using insulin pump as well as those using multiple injections of insulin. The effective use of CGM in those using multiple injections of insulin has important implications as these patients likely will not make the switch to more advanced technologies that automate insulin.
 
For more about Diabetes or the latest Continuous Glucose Monitoring (CGM) Medical Devices, drop us an email as we will send you details of a new online diabetes support group that is via a paid yearly subscription with  lots of benefits and discounts etc. Kindly include email, address, mobile contacts, age, sex and details of your diabetes condition (only for residents of United States, Canada, United Kingdom, Australia, Japan, Singapore and Malaysia, For Thailand we only except expats from these countries but no Thais or expats from other countries)

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Source : Thailand Medical news
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