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Source: COVID-19 Research  May 12, 2020  3 years, 9 months, 2 weeks, 2 days, 7 hours, 58 minutes ago

COVID-19 Research: Worrying Gastrointestinal Abnormalities Revealed In Abdominal Imaging Studies Of COVID-19 Patients

COVID-19 Research: Worrying Gastrointestinal Abnormalities Revealed In Abdominal Imaging Studies Of COVID-19 Patients
Source: COVID-19 Research  May 12, 2020  3 years, 9 months, 2 weeks, 2 days, 7 hours, 58 minutes ago
COVID-19 Research:  A new study by medical researchers from the department of radiology, Massachusetts General Hospital- Boston revealed that COVID-19 patients including those that have ‘recovered’ can have bowel abnormalities, including ischemia.
Numerous past studies have evaluated the chest imaging findings in COVID-19, which helped improve understanding of how the disease affects the lungs.
Also more recently, studies and reports have documented that gastrointestinal symptoms, liver injury, and vascular findings are common in COVID-19 patients.

Axial (A) and coronal (B) CT of the abdomen and pelvis with IV contrast in a 57-year-old man with a high clinical suspicion for bowel ischemia. There was generalized small bowel distension and segmental thickening (arrows), with adjacent mesenteric congestion (thin arrow in B), and a small volume of ascites (* in B). Findings are nonspecific but suggestive of early ischemia or infection. Credit: RSNA

Unfortunately there were no abdominal imaging research or studies conducted in detail that could help physicians understand abdominal manifestations in patients with the SARS-CoV-2 coronavirus infection. Hence, the medical researchers of this study set out to explore abdominal imaging findings in patients with COVID-19 and also of those that had recovered. Their research findings are published in the journal Radiology.
The abdominal imaging retrospective study included 412 patients consecutively admitted to a single quaternary care center from March 27 to April 10, 2020, who tested positive for COVID-19.  The cohort included 241 men (58.5%) and 171 women (41.5%), with an average age of 57 years.
Imaging records showed that 17% of patients had cross-sectional abdominal imaging, including 44 ultrasounds, 42 CT scans, and 1 MRI. Bowel abnormalities were seen on 31% of CT scans (3.2% of all patients) and were more frequent in intensive care unit (ICU) patients than other inpatients.

Coronal CT of the abdomen and pelvis with IV contrast in a 47-year-old man with abdominal tenderness demonstrates typical findings of mesenteric ischemia and infarction, including pneumatosis intestinalis (arrow) and non-enhancing bowel (*). Frank discontinuity of a thickened loop of small bowel in the pelvis (thin arrow) is in keeping with perforation. Credit: RSNA

Bowel findings included thickening and findings of ischemia such as pneumatosis (gas in the bowel wall) and portal venous gas. Surgical correlation in four patients revealed unusual yellow discoloration of bowel in three of the patients, and bowel infarction (dead bowel) in two patients.
Dr Rajesh Bhayana, FRCPC, abdominal imaging fellow in the Department of Radiology at Massachusetts General Hospital in Boston told Thailand Medical News, "We found bowel abnormalities on imaging in patients with COVID-19, more commonly in sicker patients who went to the IC.,"
It was observed in two patients who had bowel resection, pathology demonstrated ischemia with patchy necrosis (injury due to reduced arterial flow with patchy areas of cell death). Both had fibrin thrombi (blood clots) in submucosal arterioles (small arteries in the bowel wall), suggesting bowel ischemia in these patients might be caused by these small blood clots.

Non-contrast axial (A) and coronal (B) CT performed in a 54-year-old man demonstrates pneumatosis cystoides intestinalis (arrows) in a long segment of ileum. Adjacent mesenteric congestion is also noted (thin arrow). Laparotomy demonstrated no frank bowel necrosis. Low power photomicrograph (H and E, 40x) of the ileum (C) shows ischemic degenerative changes of the mucosa with villous blunting (left) and withered crypts. There is marked submucosal edema with large empty spaces consistent with pneumatosis (*). High power view (H and E, 400x) (D) of the superficial submucosa shows arterioles with fibrin thrombi (arrowheads) beneath the damaged mucosa. Credit: RSNA

Furthermore lung base findings led to a diagnosis of COVID-19 in one patient who presented with abdominal symptoms only. Of right upper quadrant ultrasounds, 87% were performed for liver laboratory findings, and 54% demonstrated a dilated sludge-filled gallbladder suggestive of cholestasis, or a decrease in bile flow.
Dr Bhayana added, "Some imaging analysis were typical of bowel ischemia, or dying bowel, and in those who had surgery we saw small vessel clots beside areas of dead bowel. Patients in the ICU can have bowel ischemia for other reasons, but we know COVID-19 can lead to clotting and small vessel injury, so bowel might also be affected by this."
From the researchers’ perspective, possible explanations for the spectrum of bowel findings in patients with COVID-19 include direct viral infection, small vessel thrombosis, or nonocclusive mesenteric ischemia.
Dr Bhayana further added, "ACE2 expression is most abundant in lung alveolar epithelial cells, enterocytes of the small intestine, and vascular endothelium suggesting that small bowel and vasculature may be susceptible to SARS-CoV-2 infection.”
The researchers added that further studies are required to clarify the cause of bowel findings in patients with COVID-19 and to determine whether SARS-CoV-2 plays a direct role in bowel or vascular injury.
Dr Bhayana added, "Our study is preliminary, and more work is needed to understand the cause of bowel findings in these patients."
Medical experts elsewhere also recommend that ‘recovered’ COVID-19 patients should also follow up with medical checkups of their gastrointestinal tract to ensure that there could be any possible prevailing issues.

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