Wishing All Our Canadian Readers A Happy Canada Day And All Our American Readers A Great And Happy Independence Day!

Source: COVID-19 Herbs  Aug 11, 2020  2 years ago
COVID-19 Herbs: Researchers Discover Potent Herbs Used In Most TCM Formulations In China Against COVID-19 Are Ephedra And Bitter Apricot
COVID-19 Herbs: Researchers Discover Potent Herbs Used In Most TCM Formulations In China Against COVID-19 Are Ephedra And Bitter Apricot
Source: COVID-19 Herbs  Aug 11, 2020  2 years ago
COVID-19 Herbs: From the beginning of the outbreak of the COVID-19 crisis in China, the Chinese health authorities brought in the top TCM (Traditional Chinese Medicine) experts to develop and test formulations against the SARS-CoV-2 coronavirus and to treat various stages of the COVID-19 disease. Some were used alone and some were used as adjuvants alongside standard pharmaceuticals including the various antivirals and anti-inflammatory agents.

Ephedra sinica 
As it became apparent that more of the pharmaceutical products were not working, the Chinese government focused massive resources on TCM research and it bore fruit as almost 14 different formulations emerged that could be used to treat the various stages of the COVID-19 disease and also depending on the specific profile of the patients.
The Chinese authorities however kept many of these formulations as state secrets and whatever formulations that were publicly disclosed in the various versions of the public medical guidelines were merely to provide competitor countries with the wrong information.
Many of these formulations were made by state owned factories and send to state hospitals to be dispensed in highly controlled ways to Chinese patients with no one ever knowing what was in these formulations. These products are also considered as controlled items and are not allowed to be exported out of the country.
The key thing however is that all these formulations worked, and despite occasional outbreaks in various provinces off and on (Expected in a massive country with a population over a billion people), China has managed to keep the situation since then under control.
In a study by researchers from Macau University and the Fujian University of Traditional Chinese Medicine that was sent for publishing on a preprint server on the 21st Of July (kindly note that all 9 researchers are currently relocated in Europe), the researchers did a detailed study of various TCM formulations that were used in China and also used the basis of TCM rules in the formulation of such preparations for the treatment of such a disease as COVID-19 using the traditional TCM system of utilizing two main key herbal pairs besides the numerous other minor herbs that had potent efficacy to treat the disease.

The researchers identified the herbs Ephedra sinica Stapf and Amygdalus Communis Vas as two herb pairs that high potential efficacy to treat the COVID-19 disease.
The study has been peer-reviewed and will be published in the BMC’s journal  of Biomolecular Science shortly https://www.researchsquare.com/article/rs-46828/v1
Both herbs are incorporated in Thailand Medical News new specially blended Therapeutic Teas that are patented and that involve new proprietary processes in its manufacture in order to obtain the right quality and quantity of phytochemicals to be released in the teas for therapeutic purposes. https://www.thailandmedical.news/news/new-therapeutic-teas-

Ephedra sinica is a plant species native to Mongolia, Russia, and Northeastern China and Northern parts of Thailand.
Amygdalus Communis Vas is a component of the kernels of bitter apricot (do not get confused with almonds as there as often been mistranslations. Also do not attempt to take any of these herbs oneself as which parts of the plants and how to treat the herbs is not divulged due to patent and proprietary rights issues. It should be noted that both if used wrongly can cause toxic and dangerous medical conditions. Ephedra can cause heart failures or issues and apricot kernels contains amygdalin, which is often marketed misleadingly as vitamin B17, and can release the toxin cyanide after it is eaten. In herbal preparations, certain portions of the bitter apricot are used and are non-toxic and the ephedra has to be pre-treated to remove the dangerous ephedrine alkaloids and phytochemicals. Also the USA FDA only allows pre-treated safe ephedra constituents to be used in any products including our teas.)
In the study the researchers identified 26 active phytochemicals in the two herbs including quercetin, kaempferol and luteolin.
Also the researchers identified 44 potential targets, which may be relate to the herbal pair against COVID-19 such as Interleukin 6 (IL-6), Mitogen-activated Protein Kinase 1 (MAPK)1, MAPK8, Interleukin-1β (IL-1β), Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) p65 subunit (RELA) and so on.
Interestingly, the protein-protein interaction (PPI) cluster demonstrated that IL-6 was the seed in the cluster, which plays an important role in connecting other nodes in the PPI network. The significant pathways mainly involved in tumor necrosis factor (TNF), Toll-like receptor (TLR), hypoxia-inducible factor-1 (HIF-1), nucleotide-binding oligomerization domain (NOD)-like receptor(NLRs).
The researchers conclude that both herbs may have therapeutic effects against COVID-19 by affecting the pathological processes such as inflammatory and immune responses, cell apoptosis, hypoxia damage and other pathological processes through multiple components, multiple targets and multiple pathways.
The researchers are now planning animal and clinical trials in Europe using these two herbs.
For more on COVID-19 Herbs, keep on logging to Thailand Medical News.

Kandel N, Chungong S, Omaar A, Xing J. Health security capacities in the context of COVID-19 outbreak: an analysis of International Health Regulations annual report data from 182 countries. Lancet 2020; 395 (10229): 1047-1053. doi: 10.1016/S0140-6736(20)30553-5.

Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med 2020; 382 (18): 1708-1720. doi: 10.1056/NEJMoa2002032.

Rothe C, Schunk M, Sothmann P, Bretzel G, Froeschl G, Wallrauch C, et al. Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany. N Engl J Med 2020; 382 (10): 970-971. doi: 10.1056/NEJMc2001468.

Zhao H, Lu X, Deng Y, Tang Y, Lu J. COVID-19: asymptomatic carrier transmission is an underestimated problem. Epidemiology and infection 2020; 148 e116. doi: 10.1017/s0950268820001235.

Jin YH, Cai L, Cheng ZS, Cheng H, Deng T, Fan YP, et al. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Military Medical Research 2020; 7 (1): 4. doi: 10.1186/s40779-020-0233-6.

Yang Y, Islam MS, Wang J, Li Y, Chen X. Traditional Chinese Medicine in the Treatment of Patients Infected with 2019-New Coronavirus (SARS-CoV-2): A Review and Perspective. Int J Biol Sci 2020; 16 (10): 1708-1717. doi: 10.7150/ijbs.45538.

Cao HX. In response to the emergence of infectious diseases, traditional Chinese medicine should do something. 2013 2013-08-14.

Liu M, Gao Y, Yuan Y, Yang K, Shi S, Zhang J, et al. Efficacy and Safety of Integrated Traditional Chinese and Western Medicine for Corona Virus Disease 2019 (COVID-19): a systematic review and meta-analysis. Pharmacological research 2020; 158.

General Office of National Health Commission of the People's Republic of China Office of National Administration of Traditional Chinese Medicine. Diagnosis and treatment of corona virus disease-19 (7 edition) China Medicine 2020; 15 (06): 801-805. doi: 10.3760/j.issn.1673-4777.2020.06.001..

Runfeng L, Yunlong H, Jicheng H, Weiqi P, Qinhai M, Yongxia S, et al. Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2). Pharmacological research 2020; 156 104761. doi: 10.1016/j.phrs.2020.104761.

Chen J, Wang YK, Gao Y, Hu LS, Yang JW, Wang JR, et al. Protection against COVID-19 injury by qingfei paidu decoction via anti-viral, anti-inflammatory activity and metabolic programming. Biomed Pharmacother 2020; 129 110281. doi: 10.1016/j.biopha.2020.110281.

Xia SJ, Chen SJ, Wu CW, Lin Y, Li CD. Novel coronavirus pneumonia diagnosis and treatment by "five differentiation " thinking. Tianjin Journal of Traditional Chinese Medicine 2020; 1-6.

Li S, Zhang B, Jiang D, Wei Y, Zhang N. Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae. BMC Bioinformatics 2010; 11 Suppl 11 S6. doi: 10.1186/1471-2105-11-S11-S6.

Cheng Y, Xiong Y. Research and Improvement of Apriori Algorithm for Association Rules. Physical Review A 2016; 1-4.

Ru J, Li P, Wang J, Zhou W, Li B, Huang C, et al. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. Journal of cheminformatics 2014; 6 13. doi: 10.1186/1758-2946-6-13.

Barton HA, Pastoor TP, Baetcke K, Chambers JE, Diliberto J, Doerrer NG, et al. The Acquisition and Application of Absorption, Distribution, Metabolism, and Excretion (ADME) Data in Agricultural Chemical Safety Assessments. Critical reviews in toxicology 2008; 36 (1): 9-35. doi: 10.1080/10408440500534362.

Rebhan M, Chalifa-Caspi V, Prilusky J, Lancet D. GeneCards: a novel functional genomics compendium with automated data mining and query reformulation support. Bioinformatics 1998; 14 (8): 656-664. doi: 10.1093/bioinformatics/14.8.656.

Hamosh A, Scott AF, Amberger JS, Bocchini CA, McKusick VA. Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Res 2005; 33 (Database issue): D514-517. doi: 10.1093/nar/gki033.

Szklarczyk D, Morris JH, Cook H, Kuhn M, Wyder S, Simonovic M, et al. The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res 2017; 45 (D1): D362-D368. doi: 10.1093/nar/gkw937.

Tan A, Huang H, Zhang P, Li S. Network-based cancer precision medicine: A new emerging paradigm. Cancer Lett 2019; 458 39-45. doi: 10.1016/j.canlet.2019.05.015.

Hahsler M, Grün B, Hornik, K. B, C. Introduction to arules-A computational environment for mining association rules and frequent item sets. Compr. R Arch. Netw., 2009.

Wang Q, Gu XH, Liu QQ. COVID-19 Chinese medicine diagnosis and treatment manual. Beijing: China Press of Traditional Chinese Medicine 2020.

Rather RA, Bhagat M. Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health. Cancer Med 2019; doi: 10.1002/cam4.1411.

Dabeek WM, Marra MV. Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans. Nutrients 2019; 11 (10): doi: 10.3390/nu11102288.

Wu W, Li R, Li X, He J, Jiang S, Liu S, et al. Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry. Viruses 2015; 8 (1): doi: 10.3390/v8010006.

Byun EB, Yang MS, Choi HG, Sung NY, Song DS, Sin SJ, et al. Quercetin negatively regulates TLR4 signaling induced by lipopolysaccharide through Tollip expression. Biochem Biophys Res Commun 2013; 431 (4): 698-705. doi: 10.1016/j.bbrc.2013.01.056.

Chen AY, Chen YC. A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention. Food Chem 2013; 138 (4): 2099-2107. doi: 10.1016/j.foodchem.2012.11.139.

Zhu L, Wang P, Yuan W, Zhu G. Kaempferol inhibited bovine herpesvirus 1 replication and LPS-induced inflammatory response. Acta Virol 2018; 62 (2): 220-225. doi: 10.4149/av_2018_206.

Zhang R, Ai X, Duan Y, Xue M, He W, Wang C, et al. Kaempferol ameliorates H9N2 swine influenza virus-induced acute lung injury by inactivation of TLR4/MyD88-mediated NF-kappaB and MAPK signaling pathways. Biomed Pharmacother 2017; 89 660-672. doi: 10.1016/j.biopha.2017.02.081.

Manzoor MF, Ahmad N, Ahmed Z, Siddique R, Zeng XA, Rahaman A, et al. Novel extraction techniques and pharmaceutical activities of luteolin and its derivatives. J Food Biochem 2019; 43 (9): e12974. doi: 10.1111/jfbc.12974.

Peng M, Watanabe S, Chan KWK, He Q, Zhao Y, Zhang Z, et al. Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin. Antiviral Res 2017; 143 176-185. doi: 10.1016/j.antiviral.2017.03.026.

Fan W, Qian S, Qian P, Li X. Antiviral activity of luteolin against Japanese encephalitis virus. Virus research 2016; 220 112-116. doi: 10.1016/j.virusres.2016.04.021.

Zhang H, Penninger JM, Li Y, Zhong N, Slutsky AS. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive care medicine 2020; 46 (4): 586-590. doi: 10.1007/s00134-020-05985-9.

Jo S, Kim S, Shin DH, Kim MS. Inhibition of SARS-CoV 3CL protease by flavonoids. Journal of enzyme inhibition and medicinal chemistry 2020; 35 (1): 145-151. doi: 10.1080/14756366.2019.1690480.

Fan J, Qin X, Li Z. Mechanism of Farfarae Flosin Qingfei Paidu Decoction against COVID-19 based on network pharmacology and molecular docking Chinese Traditional and Herbal Drugs 2020; 51 (09): 2317-2325.

Kang S, Tanaka T, Narazaki M, Kishimoto T. Targeting Interleukin-6 Signaling in Clinic. Immunity 2019; 50 (4): 1007-1023. doi: 10.1016/j.immuni.2019.03.026.

Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus [Internet]. 2020. Available from: biorxiv. org/content/10. 1101/2020, 02. 12. 945576 vl.

Huang YF, Bai C, He F, Xie Y, Zhou H. Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19). Pharmacological research 2020; 158 104939. doi: 10.1016/j.phrs.2020.104939.

Luo E, Zhang D, Luo H, Liu B, Zhao K, Zhao Y, et al. Treatment efficacy analysis of traditional Chinese medicine for novel coronavirus pneumonia (COVID-19): an empirical study from Wuhan, Hubei Province, China. Chin Med 2020; 15 34. doi: 10.1186/s13020-020-00317-x.



Aug 13, 2020  2 years ago
Source: Supplements For COVID-19
Feb 05, 2020  2 years ago
Source : Thailand Medical news