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Source: COVID-19 Genetics  Oct 29, 2020  3 years, 5 months, 2 weeks, 6 days, 3 hours, 51 minutes ago

COVID-19 Genetics: Study Shows Need For Identifying Genetic Biomarkers In COVID-19 Patients To Assess Responses To Drugs And Therapeutics

COVID-19 Genetics: Study Shows Need For Identifying Genetic Biomarkers In COVID-19 Patients To Assess Responses To Drugs And Therapeutics
Source: COVID-19 Genetics  Oct 29, 2020  3 years, 5 months, 2 weeks, 6 days, 3 hours, 51 minutes ago
COVID-19 Genetics: Genetics, genomics and personalized or precision medicine is going to play a very critical role in treating the COVID-19 disease and more researches and experts have to start adopting this approach.


 
The specific SARS-CoV-2 variant that is at play and the patient’s full genetic will determine the success of treatment protocols and therapeutics.
 
In a new TMN propelled study, researchers from Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Institut Pasteur of Shanghai, Fudan University, ShanghaiTech University and Hangzhou Institute for Advanced Study by leveraging nucleotide triphosphate analog-induced cell death, unveiled genes that affect the import, export, and metabolism of pervasively used antiviral and anti-inflammatory drugs in the treatment of COVID-19 disease.
 
Immunomodulatory agents such dexamethasone and colchicine, antiviral drugs remdesivir, favipiravir and ribavirin, as well as antimalarial drugs chloroquine phosphate and hydroxychloroquine are currently used in the combat against COVID-191-16. However, whether some of these drugs have clinical efficacy for COVID-19 is under debate. Moreover, these drugs are applied in COVID-19 patients with little knowledge of genetic biomarkers, which will hurt patient outcome.
 
In order to answer these questions, the study team designed a screen approach that could employ genome-wide sgRNA libraries to systematically uncover genes crucial for these drugs’ action.
 
Here the study findings show genes crucial for the import, export, metabolic activation and inactivation of remdesivir, as well as genes that regulate colchicine and dexamethasone’s immunosuppressive effects. The study findings provide preliminary information for developing urgently needed genetic biomarkers for these drugs. Such biomarkers will help better interpret COVID-19 clinical trial data and point to how to stratify COVID-19 patients for proper treatment with these drugs.
 
The study findings were published on a preprint server and are currently being peer-reviewed for publication into a journal.
https://www.biorxiv.org/content/10.1101/2020.10.26.356279v1

The world-wide spread of COVID-19, caused by the SARS-CoV-2, has paralyzed health systems and economies worldwide. As the quest for effective drugs and vaccines continues, scientists and healthcare workers turned towards drug repurposing efforts for treating this infection.
 
Certain notable examples of drugs currently used in this combat against COVID-19 are immunomodulatory agents such as dexamethasone and colchicine, antiviral drugs remdesivir, ribavirin, and favipiravir, as well as antimalarial drugs chloroquine and hydroxychloroquine. (although some have already been deemed as ineffective and even lethal in some cases, man are still being used in protocols in various countries)
 
Alarmingly due to the urgency and lack of relevant knowledge, most of