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Source: Thailand Medical News  Jan 28, 2020  2 years ago
Common Green Algae Improves Gastrointestinal Health According To New Study
Common Green Algae Improves Gastrointestinal Health According To New Study
Source: Thailand Medical News  Jan 28, 2020  2 years ago
For many years, a widespread, fast-growing algae plant called Chlamydomonas reinhardtii  the green, single-celled organism, which primarily grows in wet soil, has served as a model species for research topics spanning from algae-based biofuels to plant evolution. While other species of algae have been used as dietary nutraceuticals that provide beneficial oils, vitamins, proteins, carbohydrates, antioxidants and fiber, the benefits of consuming C. reinhardtii were previously unexplored.

Now, medical researchers from the University of California San Diego recently completed the first study examining the effects of consuming C. reinhardtii algae and demonstrated that the algae improves human gastrointestinal issues associated with irritable bowel syndrome (IBS) such as diarrhea, gas and bloating. Results of the project are published in the Journal of Functional Foods.
Principal investigator and algae expert Dr Stephen Mayfield, a distinguished Professor in University of California, San Diego's Division of Biological Sciences and co-director of the Food and Fuel for the 21st Century Program (FF21) told Thailand Medical News, "People have been looking at this algae for decades, but this is the first study to show what many of us have suspected ie it's good for you. This is exciting because it demonstrates a clear benefit: If you have IBS-like symptoms, this is good for you."
For almost a decade now, researchers in Mayfield's laboratory have been exploring C. reinhardtii algae as a cost-competitive and sustainable source of valuable plant-based products, specifically pharmaceuticals and biofuels. Now, working with several collaborators, including UC San Diego's John Chang (School of Medicine), Rob Knight (School of Medicine, Jacobs School of Engineering and Center for Microbiome Innovation) and the San Diego-based startup Triton Algae Innovations, they turned their attention towards investigating the algae as a nutritious food additive for improving human health.

Graphical abstract for algae and human gastrointestinal health study. Credit: Mayfield Lab, UC San Diego
The algae C. reinhardtii biomass used in the study, which was grown by Triton Algae Innovations, was subject to rigorous safety testing and designated as "Generally Recognized As Saf e" by the U.S. Food and Drug Administration, green-lighting the use of the organism in a human study.
Initial data in mouse studies demonstrated that consuming C. reinhardtii algae significantly reduced the rate of weight loss in mice with acute colitis, which is generally linked to inflammation of the digestive tract. Building off these results, the researchers set out to test for a similar effect when the algae was consumed by human volunteers, including those with and without symptoms associated with IBS. Volunteers consumed daily spoonfuls of powdered C. reinhardtii biomass and reported their gastrointestinal health for one month. Of the hundreds of interested participants in the project, data from 51 volunteers met the study's requirements for inclusion in the final data analyses.

The Green Algae in powedred form.

Study results showed that participants who suffered from a history of frequent gastrointestinal symptoms reported significantly less bowel discomfort and diarrhea, significantly less gas or bloating and more regular bowel movements.
Dr Frank Fields, a research scientist in Mayfield's lab and lead author of the paper further added, "The benefits of consuming this species of algae were immediately obvious when examining the data from both mice and humans who suffered from gastrointestinal symptoms. I hope that this study helps destigmatize the thought of incorporating algae and algae-based products into your diet, it is a fantastic source of nutrition and we have now shown that this species of algae has additional benefits to animal and human health."

For the human digestion study, algae were grown in a large stainless steel fermentation
tank, similar to fermentation tanks seen at beer breweries. A smaller bench-top fermentation
tank, or bioreactor, is pictured. Credit: Frank Fields, UC San Diego

Research volunteers also were provided with stool sampling kits and sent samples to the American Gut Project, a citizen science effort led by Knight and his lab, to assess any changes in their microbiomes. The results indicated that the gut microbiome composition remained diverse, which is typical of healthier individuals, and that no significant changes to the composition of their gut microbiome occurred during the study as a result of consuming the algae.
The medical researchers say much more testing with larger groups of participants across longer time periods is needed. At this point, they are unclear about how the algae works to improve gastrointestinal health. The scientists believe the benefits could be traced to a bioactive molecule in algae or perhaps a change in gene expression of gut bacteria caused by algae consumption.
Reference : Francis J. Fields et al, Effects of the microalgae Chlamydomonas on gastrointestinal health, Journal of Functional Foods (2019). DOI: 10.1016/j.jff.2019.103738


Feb 05, 2020  2 years ago
Source : Thailand Medical news