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Source: Thailand Medical News  Jan 16, 2020  4 years, 3 months, 3 days, 14 hours, 11 minutes ago

Cancer Genes That Promote Metastasis Identified, Paving The Way For Therapeutics To Prevent Cancer Spread

Cancer Genes That Promote Metastasis Identified, Paving The Way For Therapeutics To Prevent Cancer Spread
Source: Thailand Medical News  Jan 16, 2020  4 years, 3 months, 3 days, 14 hours, 11 minutes ago
Two cancer-promoting genes MYC and TWIST1 co-opt immune system cells to enable cancer cells to spread, but blocking a key step in this process can help prevent the disease from developing.

These research findings, published today in eLife, may help clinicians to identify cancer patients at risk of metastasis, a process where cancer cells spread to other parts of the body. They may also inform the development of new strategies to prevent or treat metastasis.



Lead author Dr Renumathy Dhanasekaran, a Ph.D. student in the Division of Gastroenterology and Hepatology at Stanford University, California explained to Thailand Medical News, "Most cancer-related deaths are caused by metastasis, but there are currently no treatments available to stop it. The main goal of our research is to understand how cancer-causing genes enable metastasis and use that information to identify targeted therapies that may prevent it."

Dr Dhanasekaran and her colleagues genetically engineered mice to express both MYC and TWIST1 and found that these two major cancer-promoting genes led to metastases. They also saw that the cancer cells produced inflammation-promoting molecules Ccl2 and Il13, which attract immune ce