BREAKING! COVID-19 News: Autopsies Of Deceased COVID-19 Patients Reveal Distinctive Lung Features
Medical researchers from Harvard Medical School’s Brigham and Women's Hospital say that autopsies of deceased covid-19 patients reveal distinctive lung features primarily being damage on the various pulmonary blood vessels.
In a research which was published in the New England Journal of Medicine (NEJM)
, senior researcher, Dr Steven J. Mentzer, MD, a thoracic surgeon at Brigham and Women's Hospital, and a team of international researchers examined seven lungs obtained during autopsy from patients who died of COVID-19. https://www.nejm.org/doi/10.1056/NEJMoa2015432
The researchers compared this group to seven autopsied lungs obtained from patients who died of acute respiratory distress syndrome secondary to influenza A (H1N1) infection as well as to 10 age-matched uninfected control lungs.
Though both COVID-19 and influenza are the same category of virus and both infect the respiratory tract there were some distinct differences. While the lungs shared some common features, there were distinctive features related to blood vessels seen in the lungs of patients who had died of COVID-19.
The research team observed that COVID-19 damaged the endothelial cells (vascular lining cells), causing severe endothelial injury.
It was observed that COVID-19 patients showed widespread blood clotting as well as new vessel growth, the latter likely a result of the body's response to the virus.
The study team also saw signs of a distinctive pattern of pulmonary vascular disease progression in some cases of COVID-19 compared to that of equally severe influenza virus infection.
Among some of the key points are:
-COVID-19 is a respiratory virus that causes a vascular disease.
-The extensive damage to vascular cells helps explain the serious blot clotting observed in patients.
-Significantly, a unique response, intussusceptive angiogenesis (IA), is the way the body compensates for the thrombosis and blood vessel damage.
-Also damaged blood vessels may also underlie other problems seen, such as COVID toe, children with Kawasaki, stroke, and other seemingly unrelated problems seen with COVID-19.
This research indicates the need for more research on angiogenesis and the vascular effects of COVID-19.
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