Researchers Discover Lipoteichoic Acid From Probiotic Lactobacillus Paracasei Which Can Aid In Aging-Related Leaky Gut And Inflammation
Medical researchers from Wake Forest School of Medicine, North Carolina have identified a dead probiotic that reduces age-related leaky gut
in older animal models.
The results from the study is published in the journal GeroScience
Past research has indicated that leaky gut
, in which microbes and bacteria in the gut leak into the blood stream through holes or cracks in the intestinal lining, causes an increase in low-grade inflammation
, and these conditions are common in older people. This resulting inflammation
is thought to play a role in the development of many age-related diseases, such as diabetes, obesity, cancer, cardiovascular disease and decline in physical and cognitive functions.
Dr Hariom Yadav, Ph.D., assistant professor of molecular biology at Wake Forest School of Medicine and principal investigator of the study told Thailand Medical
News,"We know that probiotics are instrumental in maintaining a healthy gut and preventing leakage, but there isn't much data available to pinpoint which ones work and which ones don't. Determining the strain that is most effective at reducing leaky gut
would help us target more effective strategies to address the problem, and help explain why probiotics
work for some people but not others."
For the study, Yadav's team first screened eight strains of human-origin probiotics
in roundworms, a commonly used model with a short lifespan of 11 to 20 days. They discovered that a strain of Lactobacillus paracasei (D3-5
), even in the non-viable or heat-killed form, extended the roundworms' life span.
The researchers then tested their initial findings in mice. The results showed that feeding heat-killed D3-5
to older mice prevented high fat diet-induced metabolic dysfunctions, decreased leaky gut
, and improved physical and cognitive functions.
Dr Yadav added, "Not only did we determine which probiotic
strain was the most effective in preventing leaky gut
, we also showed that the dead version of that probiotic
had the same benefits.This is the first-of-its kind study to show that a component lipoteichoic acid
, from the cell wall of a dead probiotic induced changes in the gut microbiome and mucin production, thereby reducing leaky gut
in elderly mice.”
Dr Yadav further added,"We think our findings could be very useful to the food and supplement industries because dead probiotics
have the potential t
o be more stable and have a longer shelf life than live probiotics
Dr Yadav has filed a provisional patent application for D3-5.
Already many supplement companies has approached him and there is a high possibility that commercial supplements of lipoteichoic acid
will be available in the shelves as early as the first quarter of 2020.
Reference : Shaohua Wang et al, Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice, GeroScience (2019). DOI: 10.1007/s11357-019-00137-4