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BREAKING NEWS
Source: NeuroCOVID  Oct 24, 2021  2 years, 5 months, 3 weeks, 5 days, 3 hours, 11 minutes ago

BREAKING! German Scientists Discover That SARS-CoV-2 Main Protease Mpro Causes Microvascular Brain Pathology!

BREAKING! German Scientists Discover That SARS-CoV-2 Main Protease Mpro Causes Microvascular Brain Pathology!
Source: NeuroCOVID  Oct 24, 2021  2 years, 5 months, 3 weeks, 5 days, 3 hours, 11 minutes ago
NeuroCOVID: A new study by researchers from the Institute for Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck-Germany has alarmingly found that the SARS-CoV-2 main protease mpro causes microvascular brain pathology cleaving NEMO (The essential modulator of nuclear factor-κB) in brain endothelial cells!

 
The study findings were published in the peer reviewed journal: Nature Neuroscience. https://www.nature.com/articles/s41593-021-00926-1
 
To date, it has been found that a considerable proportion of patients, up to 84% of those with severe COVID-19, show neurological signs and symptoms including anosmia, epileptic seizures, strokes, loss of consciousness and confusion. Typically, COVID-19 can present with the clinical picture of encephalopathy. Beyond 4 weeks after onset, the post-acute COVID-19 syndrome includes cognitive impairment and a range of psychiatric symptoms and may affect up to 76% of patients. https://pubmed.ncbi.nlm.nih.gov/32294339/
 
https://pubmed.ncbi.nlm.nih.gov/32637987/
 
https://pubmed.ncbi.nlm.nih.gov/32882182/
 
https://pubmed.ncbi.nlm.nih.gov/33753937/
 
Though a direct infection of the brain remains a matter of debate, SARS-CoV-2 viral genomes were detected in the brain and cerebrospinal fluid (CSF) of some patients, supporting the notion that SARS-CoV-2 gains access to the brain.
https://pubmed.ncbi.nlm.nih.gov/32314810/
 
https://pubmed.ncbi.nlm.nih.gov/32402155/
 
The viral RNA has been found in blood and virus-like particles or viral proteins in brain endothelial cells, suggesting that SARS-CoV-2 reaches the brain by a hematogenous route. In line with a vascular infection, endothelial cells in other organs have been identified as targets of SARS-CoV-2 infection. In p