Thailand Medical News - For All The Latest Breaking Medical News, Health News, Research News, COVID-19 News, Outbreak News, Dengue News, Glaucoma News, Diabetes News, Herb News, Phytochemical News, Heart And Cardiology News, Epigenetic News, Cancer News,

BREAKING NEWS
Source: Thailand Medical News  Jan 15, 2020  4 years, 3 months, 4 days, 13 hours, 7 minutes ago

Researchers Develop New Treatment Protocol For Drug Resistance Advanced Bile Duct Cancer

Researchers Develop New Treatment Protocol For Drug Resistance Advanced Bile Duct Cancer
Source: Thailand Medical News  Jan 15, 2020  4 years, 3 months, 4 days, 13 hours, 7 minutes ago
A research led by medical oncologists at The Ohio State University Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC—James) shows how resistance to a promising targeted drug develops in patients with a rare, lethal cancer of the bile ducts called cholangiocarcinoma.



The research, reported in the journal Molecular Cancer Therapeutics, also suggests that adding another drug at the time of progression might re-sensitize tumor cells to the initial drug, called an FGFR inhibitor.

Study leader Dr Sameek Roychowdhury, MD, Ph.D., a medial oncologist and researcher at the OSUCCC—James told Thailand Medical News, "While the majority of patients with FGFR-positive cholangiocarcinoma benefit from new FGFR inhibitors in clinical trials, most patients unfortunately develop cancers resistant to the drugs. We believe that this study is an important step in understanding drug resistance, and improving the treatment of this and other cancers caused by abnormal FGFR gene mutations."

Research findings also suggest that monitoring fragments of circulating tumor DNA for acquired mutations that cause resistance to FGFR inhibitors may reveal the presence of resistance mutations and mark the time a patient should begin taking the additional drug, an mTOR inhibitor.

Typically, the successful treatment