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Source: COVID-19 Herbs  Nov 23, 2020  3 years, 4 months, 3 weeks, 4 days, 15 hours, 17 minutes ago

COVID-19 Herbs: Phytochemicals Ellagic Acid, Gallic Acid, Punicalagin And Punicalin Extracted From Pomegranate Peels Could Inhibit SARS-CoV-2 Virus

COVID-19 Herbs: Phytochemicals Ellagic Acid, Gallic Acid, Punicalagin And Punicalin Extracted From Pomegranate Peels Could Inhibit SARS-CoV-2 Virus
Source: COVID-19 Herbs  Nov 23, 2020  3 years, 4 months, 3 weeks, 4 days, 15 hours, 17 minutes ago
COVID-19 Herbs: In new research by scientists from the faculty of medicine, University of Banja Luka-Bosnia/Herzegovina and the Institute for Medicinal Plant Research Belgrade-Serbia, that involved using computational molecular docking studies, it was found that the phytochemicals Ellagic Acid, Gallic Acid, Punicalagin and Punicalin extracted from pomegranate peels could inhibit the SARS-CoV-2 coronavirus.  


 
The desperate search for an effective COVID-19 therapy has attracted a great deal of scientific interest due to its unprecedented public health care system overload worldwide. As of this evening the total number of global COVID-19 infections has reached 58.8 million while the total number global COVID-19 deaths have reached almost 1.4 million. The situation is fast accelerating and it is not expected that even the vaccines that will be introduced shortly by the tainted American drug regulatory body will offer proper protection against the new SARS-CoV-2 coronavirus strains in circulation and in fact could backfire badly in the later stages. It is best for proponents of these vaccines to have themselves and their loved one vaccinated first and for others to wait for at least 4 to 6 months to see the effects on these individuals.
 
The study team carried out a research to investigate the in silico effects of the most abundant pomegranate peel extract constituents on the multi-step process of SARS-CoV-2 internalization in the host cells. Binding affinities and interactions of ellagic acid, gallic acid, punicalagin and punicalin were studied on four selected protein targets with a significant and confirmed role in the process of the entry of virus into a host cell. The protein targets used in this study were: SARS-CoV-2 spike glycoprotein, angiotensin-converting enzyme 2, furin and transmembrane serine protease 2.
 
The study findings indicated that the constituents of pomegranate peel extracts, namely punicalagin and punicalin had very promising