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Source: COVID-19 Alerts  Nov 24, 2020  3 years, 4 months, 3 weeks, 3 days, 18 hours, 30 minutes ago

COVID-19 Alerts: Study By University Of Pittsburgh And Harvard Shows That SARS-Cov-2 Spike Deletion Mutations May Evade Current Vaccine Candidates

COVID-19 Alerts: Study By University Of Pittsburgh And Harvard Shows That SARS-Cov-2 Spike Deletion Mutations May Evade Current Vaccine Candidates
Source: COVID-19 Alerts  Nov 24, 2020  3 years, 4 months, 3 weeks, 3 days, 18 hours, 30 minutes ago
COVID-19 Alerts: A new research that is among many that is emerging is indicating that natural deletions in the SARS-CoV-2 spike glycoprotein is driving antibody escape and many of the current vaccine candidates may end up being useless or worse even contribute to the phenomenon of ADE or antibody-dependent enhancement.


 
The new research by scientist from the University of Pittsburg and Harvard Medical School serves as yet another warning of things to come.
 
According to the researchers, Zoonotic pandemics follow the spillover of animal viruses into highly susceptible human populations. Often, pandemics wane, becoming endemic pathogens. Sustained circulation requires evasion of protective immunity elicited by previous infections. The emergence of SARS-CoV-2 has initiated a global pandemic. Since coronaviruses have a lower substitution rate than other RNA viruses this gave hope that spike glycoprotein is an antigenically stable vaccine target.
 
However, the study team describes an evolutionary pattern of recurrent deletions at four antigenic sites in the spike glycoprotein. Deletions abolish binding of a reported neutralizing antibody. Circulating SARS-CoV-2 variants are continually exploring genetic and antigenic space via deletion in individual patients and at global scales. In viruses where substitutions are relatively infrequent, deletions represent a mechanism to drive rapid evolution, potentially promoting antigenic drift.
 
The study findings were published on a preprint server and are currently being peer reviewed. https://www.biorxiv.org/content/10.1101/2020.11.19.389916v1
 
Already Thailand Medical news had published another study by researchers from multiple institutions about the rise of antibody resistance once antibody protocols and vaccines are introduced into the general populations.