Oct 16, 2018
What Causes Neuroblastoma?
What Causes Neuroblastoma?
  Oct 16, 2018

Neuroblastoma is a rare childhood cancer that develops from immature nerve cells called neuroblasts. “Neuro” means nerve, while “blast” refers to immature cells and “oma” means a tumor or group of cells. Neuroblastoma usually develops in infants under the age of five years and very rarely in older children, teenagers and adults.

Neuroblastoma often arises in the abdomen, typically in and around the adrenal glands or the nerve tissue at the back of the abdomen. However, this cancer can also develop in other regions of the abdomen or in nerve tissue found in the neck, chest, spine, or pelvis. In some cases, neuroblastoma can spread to areas other than the site of origin, most commonly the bone marrow, bones, liver, lymph nodes and skin. This occurs in approximately 50% of children with the condition.


In general, cancer arises due to a genetic mutation that enables healthy cells to continue growing when they would usually have responded to signals to stop growing. These cells then proliferate in an out of control manner and grow until they eventually form a mass or tumor.

As a fetus develops in the womb, neuroblasts eventually mature into fully formed nerve cells, nerve fibers and the cells that form the adrenal glands. The majority of neuroblasts mature by birth, although a small proportion of immature neuroblasts may be present in newborns. Usually, these immature nerve cells develop into mature cells, but in the case of neuroblastoma they go on to form a tumor.

In cases where there is a family history of neuroblastoma, children are at an increased risk of developing the disease. However, familial neuroblastoma is only though to account for a very small proportion of cases and usually, the cause of the condition is not clear.

Chromosomal and molecular markers

The most significant of these markers is the oncogene MYCN, the official name of which is “v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog.” This oncogene is overexpressed in around 25% of neuroblastoma cases. This overexpression occurs due to amplification of the distal arm of chromosome 2. The number of MYCN gene copies varies widely between neuroblastomas, but is usually found to be between 50 and 100. Amplification of this gene is associated with more aggressive disease. Even in the presence of favorable factors such as low-stage disease, amplification of MYCN is associated with rapid cancer progression and a poor prognosis.Over the last couple of decades, researchers have identified several molecular and chromosomal abnormalities in patients with neuroblastoma. These abnormalities serve as biological markers of the condition and have been evaluated to establish their value in determining patient prognosis. Some of these markers are now used as part of risk assignment strategies.


Important prognostic factors used for risk assessment and treatment decisions for patients with neuroblastoma are age, cancer stage and the features of tumor cells. Prognosis and treatment outcomes vary widely among these patients. Low-risk or intermediate-risk disease is often associated with an excellent prognosis and outcome, while high-risk disease is associated with a very poor outcome, even when patients are assigned intensive therapy. Unfortunately, among patients aged more than 18 months, around 75% present with metastatic cancer, typically in the bone marrow, bone, liver and lymph nodes. Less than 50% of these patients are successfully treated, even when they are administered intensive therapy followed by autologous stem cell or bone marrow rescue.