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BREAKING NEWS
Source: SARS-Cov-2 Research  Jun 26, 2021  2 years, 9 months, 3 weeks, 1 day, 23 minutes ago

Yet Another Alarming Research Finding! Persistence of SARS CoV-2 S1 Protein Found in CD16+ Monocytes Of Post COVID-19 Patients Up To 15 Months After So-Called Recovery!

Yet Another Alarming Research Finding! Persistence of SARS CoV-2 S1 Protein Found in CD16+ Monocytes Of Post COVID-19 Patients Up To 15 Months After So-Called Recovery!
Source: SARS-Cov-2 Research  Jun 26, 2021  2 years, 9 months, 3 weeks, 1 day, 23 minutes ago
SARS-CoV-2 Research: A new research by scientist from California, Massachusetts, New York, Orlando and also Costa Rican researchers have discovered that in patients having being deemed as recovered from COVID-19 but are still suffering from Long COVID conditions, it was found that even 15 months later, there was SARS-CoV-2 S1 protein found in the CD16+ monocytes of these patients. The study has numerous implications that need further studies to verify including the fact that viral persistence is present in recovered COVID-19 patients are concealing themselves in reservoirs (The CD16+ monocytes could even be serving as reservoirs for the virus or its spike proteins) , that the SARS-CoV-2 virus could be directly attacking the intermediate and non-classical monocytes as what many previous studies had even suggested in the past, that the spike protein could also playing a key role in long COVID-19 manifestations.



According to the study abstract, “The recent COVID-19 pandemic is a treatment challenge in the acute infection stage but the recognition of chronic COVID-19 symptoms termed post-acute sequelae SARS-CoV-2 infection (PASC) may affect up to 30% of all infected individuals. The underlying mechanism and source of this distinct immunologic condition three months or more after initial infection remains elusive. The study team investigated the presence of SARS-CoV-2 S1 protein in 46 individuals. The team analyzed T-cell, B-cell, and monocytic subsets in both severe COVID-19 patients and in patients with post-acute sequelae of COVID-19 (PASC). The levels of both intermediate (CD14+, CD16+) and non-classical monocyte (CD14Lo, CD16+) were significantly elevated in PASC patients up to 15 months post-acute infection compared to healthy controls (P=0.002 and P=0.01, respectively). A statistically significant number of non-classical monocytes contained SARS-CoV-2 S1 protein in both severe (P=0.004) and PASC patients (P=0.02) out to 15 months post infection. Non-classical monocytes were sorted from PASC patients using flow cytometric sorting and the SARS-CoV-2 S1 protein was confirmed by mass spectrometry. Cells from 4 out of 11 severe COVID-19 patients and 1 out of 26 also contained SARS-CoV-2 RNA. Non-classical monocytes are capable of causing inflammation throughout the body in response to fractalkine/CX3CL1 and 70 RANTES/CCR5.
The study findings were published on a preprint server and are currently being peer reviewed. https://www.biorxiv.org/content/10.1101/2021.06.25.449905v1

Already Thailand Medical News had suggested through an unproven hypothesis that the SARS-CoV-2 coronavirus was much more dangerous than HIV as it was attacking the various components of the human immune system including the T Cells and was disrupting numerous immune pathways.