Preliminary Studies Shows That Emerging BA.2 Subvariants Unlike Omicron Attacks Lungs Aggressively, Not Easily Detectable. T-Cells Offers No Protection!
Preliminary data from current studies underway in UK (University of Cambridge) and also In Hong Kong (University of Hong Kong) that have yet to be published are indicating that the new emerging subvariants of BA.2 such as the BA.2.2 and the BA.2.3 are totally different from the initial Omicron BA.1 and BA.1.1 variants especially in terms of pathogenesis.
It has been found that the newer emerging BA.2 subvariants are far more aggressive in terms of attacking the lower respiratory tract and the lungs and tends to replicate extremely faster in lung tissues. Hence it can be seen in all the new cases of infection, acute respiratory distress syndrome (ARDS) and severe lung damage is being witnessed and also the need for oxygen supplementation.
Furthermore, not only are the new BA.2 subvariants far more fusogenic and lead to faster disease severity, it has been also speculated by the researchers in the ongoing studies that more different host receptors could be at play this time and not just the ACE-2 receptors!
The researchers also warned that the early infection stages and pathogenesis is also slightly different from other previous variants in that upon infection, the newer BA.2 subvariants do not replicate in the upper respiratory tract that much and also they do not trigger the immune system as they are effective in disrupting the host immune system and bypassing it till heavy viral loads manifest in the lungs.
The details of the studies should be published in preprint servers in the coming week.
Separately, physicians in Hong Kong and also China are warning that the new BA.2 subvariants are not easily detectable by most of the current ATK test kits. (Rapid antigen test kits) and that most infected individuals are either asymptomatic or experience mild symptoms like dry coughs, 'scratchy throats', throat irritation and slight runny noses and low fevers and body pains until disease severity sets in.
Another team of Japanese researchers from University of Tokyo and Kumamoto University are warning that the newer BA.2 subvariants are not only more immune evasive and that both vaccine-induced immunity and natural immunity via previous infections offer not much protection not only against infection or reinfection but also against disease severity and risk of mortality. Further they are warning that the BA.2 subvariants are causing far more severe lymphopenia even in mildly and moderately infected BA.2 subvariant patients and believe that even the CD4, CD8 and CD 19 T cells are being attacked by the newer SARS-CoV-2 variants.
Alarmingly, this resonates with a study published a few days ago that SARS-CoV-2 virus is truly attacking the T Cells including the CD4 cells just like HIV and causing immunodeficiency issues. https://www.nature.com/articles/s41392-022-00919-x
Thailand Medical News
has been reporting about how the virus affects the CD4, CD8 and CD19 T cells since mid-2020.
(Kindly use the search function of our site and key in CD4, or CD8 or T-cells or lymphopenia, there are so many other review articles of published peer reviewed and preprint studies showing how the SARS-CoV-2 attacks, disrupts and dysregulates the T cells and the host immune system.)
Unfortunately, those controlling the COVID-19 narratives and those supporting the vaccine agendas starting promoting fallacies about induced T cell protection by the vaccines or even about the role of T cells in natural immunity etc when in reality the SARS-CoV-2 is actually causing serious immunodeficiency issues in all who have been exposed to the virus!
Thailand Medical News also hypothesizes based on preliminary data that as crazy as it may sound, this time round, even an infection with a BA.2 subvariant will not offer protection against reinfections with the same variant due to the way that it can dysregulate the immune system. Hence, expect constant reinfections for those who survive!
The coming surges should indeed be fun times for all.
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