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Source: COVID-19 Pandemic-Nikita K. Alexandrov  Jun 14, 2020  1 year ago
MUST READ! COVID-19 Pandemic-Need For An ‘Outside The Box Approach’ For Immediate Solutions To A Crisis That Is Much More Serious That It Seems
MUST READ! COVID-19 Pandemic-Need For An ‘Outside The Box Approach’ For Immediate Solutions To A Crisis That Is Much More Serious That It Seems
Source: COVID-19 Pandemic-Nikita K. Alexandrov  Jun 14, 2020  1 year ago
COVID-19 Pandemic: The following is extracted from an original article by Nikita K. Alexandrov, BChem, MBA.

Alexandrov is a private researcher based in US who had himself contracted COVID-19 and while initially indirectly aiding a private vaccine development project in Canada, he decided to switch to working with a consortium of international researchers, scientific leaders and also front-line doctors and patient advocates. Utilizing computational programs, natural language processing and deep learning algorithms to review research publications and data, and also getting feedback from hundreds of patients, the following are some interesting conclusions that warrants further research and exploration:
-The SARS-CoV-2 coronavirus mode of transmission is similar to the common cold, like a lot of other coronaviruses, with high affinity for human receptors, it has the ability to instantly and dramatically shift your immune system ie cytokine/interferon ratios and the nasty side effect of releasing papain like proteases when it is destroyed by your immune system. The closest parallel could be the condition of neuroinvasive HIV, where most of the damage is from secondary infections.
-Interestingly, the SARS-CoV-2 coronavirus seems to instantly wake up all ones’ dormant neurotrophic viruses like Epstein-Barr (90% adult population prevalence), HSV (60%), HPV (80%+), HHV (85%+), CMV (45%+), etc. These are responsible for the strange rashes, oscillating fever, neurological issues and partly for the blood attack. COVID19 is mostly a central nervous system and blood disease. If you lose your sense of smell from so much cranial nerve damage, you can expect that is not the only thing you will lose in the long term untreated.
-Another observation is that SARS-CoV-2 seems to integrate with Anaerobic bacteria like Prevotella sp. which is the second part of the lung/blood attack mechanism, these bacteria are known to require iron so they seem to shuttle iron out of your red blood cells (already tampered by HPV-B19 affecting blood cell precursors in the bone marrow), leading to blood issues, cytokine storms and a shift of the blood saturation curve. This creates a situation where someone can have fatal blood oxygen levels for long periods not correlated with lung damage. Integration with anaerobic bacteria could indicate how SARS-CoV-2 is able to stay active on surfaces longer than any known RNA virus, why some people seem to be minimally infectious while others with a potential respiratory co-infection may become “supershedders”.
-The commonly observed ground glass opacities seem to be caused by a dramatic shift in blood saturation curve at the same time that papain like proteases are chemically  ‘softening’ the lungs -almost a chemical collapse caused by neurotrophic viruses, Prevotella sp. and viral breakdown products. Genetic analysis is finding indications of Prevotella sp. and other anaerobic bacterial involvement as well as a strong correlation between severe cases and Prevotella sp. overgrowth.
-Importantly there is no real “recovery” from COVID-19, s imilar to SARS and MERS, there will be long term neurological issues caused by neurotrophic viral reactivation cascades, neural inflammation, etc. Until the neuroimmunology is modulated, the hypoxia factors, neuroimmunology, etc will cause constant reactivation cascades leading to: neural-inflammation, de-mylination events, neuropathic nerve symptomatology, etc. It appears SARS-CoV-2 may even travel through the olfactory nerves into the nervous system and straight to the frontal cortex ACE2 receptors via the seratonin transporter.
-In reality, asymptomatic infection is much more widespread than mentioned, blanket testing, testing of sewage, etc indicates double digit antibody rates in some metro areas. While everyone is looking out for a pneumonia, they are ignoring the symptoms of 99%+ of cases: brain fog, headaches, nightmares, GI unbalance, fatigue, confusion, anxiety and other symptoms of microbiome unbalance and neural inflammation.
The actual ramifications of this understanding are both horrifying and more hopeful than any medical system or media system is portraying. With the right treatments fatality can be eliminated and asymptomatic carriers returned to perfect health. 2020 is a coin flip, either we get serious about non-political data driven decisions or a large part of the human population will be chronically ill.
These findings that need to be explored further indicate that there will not be a real return to 100% for people that were infected, even asymptomatically - we can expect dramatic increases in MS, Alzheimers, Major Depressive Disorder, etc as the population deals with neural inflammation and direct CNS attack manifesting in different ways. Every scientist and doctor should review the recovery groups on Facebook and other private groups, thousands of people with months of neurological and cardiovascular symptoms, many of them under 40 - doctors telling all of these patients that it is in their heads, blood work is fine. I wonder what would happen if these physicians stopped focusing on blood counts (cells can be present but still tampered) and tested for ESR (erythrocyte sedimentation rate), endotoxins and a large panel of inflammatory biomarkers?
Although many scientists are focusing on the ACE2 receptor, it seems to be a red herring. Tissue studies have shown that the level of ACE2 receptor expression does not correlate to the level of viral attack, this is not a pneumonia. The ACE2 receptors mostly expressed are associated with lipid tissues, urinary system, GI system and reproductive system. This seems to indicate why obese patients have a higher fatality rate and diabetes is the number one co-morbidity. https://www.proteinatlas.org/ENSG00000130234-ACE2/tissue
The early reports of tampered sperm cells could also be expected to extend to female reproductive organs and cause infertility in both sexes -  the clinical signs of which have been seen anecdotally in lowered sperm motility and lack of proper ovulation. Researchers have seen “co-infection” of SARS-CoV-2 and neurotrophic viruses like EBV, IgG/IgM ratios should be studied to understand if it is a new infection or reactivation of a dormant infection as this has disruptive ramifications in treatment. https://www.researchsquare.com/article/rs-21580/v1
The usage of blood brain crossing antivirals like gancyclovir or safer next-generation BBB crossing antivirals seem to correlate to spontaneous recoveries in our observations. Treating the attack of prevotella on the blood using gram negative relevant antibiotics seems to correlate with rapid increases in blood oxygen. Heparin, iron chelation therapy and altitude sickness treatments should be used to modulate the blood cell dynamics as it is the largest attack surface area in the body. Since this is not a pneumonia, intubation should be avoided at all costs and hyperbaric oxygen therapy should be used instead as very early data indicates over 50% fatality rates for intubation and rapid recovery for hyperbaric oxygen treatment. https://www.magonlinelibrary.com/doi/full/10.12968/jowc.2020.29.Sup5a.S4
Our research group is studying advanced neuroimmunology approaches which used scaffolds derived from natural products, people that are taking these very specific natural products seem to get spontaneous recovery of neurological symptoms and move toward full recovery very quickly. By directly modulating neuroimmunology, it may not be required to use broad antivirals which can have complex side effects on many systems of the body. A naturalistic neural engineering industry has been kicking at the door for a long time, and investors suspect the next mega-blockbuster drug will be a new concept around treating neurodegeneration. https://www.spglobal.com/marketintelligence/en/news-insights/latest-news-headlines/53892299
Interestingly, the African military is deploying Covid Organics drink door to door as it contains Wormwood which has compounds that are known to act on a similar mechanism as Chloroquine, without the cardiac liability. The compounds in wormwood seem to be a clinical validated approach for anti-malarial activity, the same mechanism which makes chloroquine/HCQ seemingly effective for COVID19. The mechanism is speculated to be a modification of the red blood cell surface immunology, the largest attack surface area in the body. The actual mechanisms for antimalarial activity of chloroquine are not known, even though it has been a frontline therapy for more than 50 years and more than 300 metric tons of raw material is used globally, with the largest user being the US for lupus and other CNS indications. https://pubmed.ncbi.nlm.nih.gov/28732806/
While it is not within our standard medical paradigm to use biocomplex natural products, this approach seems to be helping before Pharma can step in with synthetic drugs. Grapefruit seed extract seems to modulate neuroimmunology and while it has interactions with other drugs, there is a large body of anecdotal observations that it seems to deactivate neuroinvasion in people suffering from COVID19 long term neurological issues. Turmeric has known effects on the nervous system, blood and immune system and anecdotal observations indicate it would be a good bet with a large therapeutic index. Detailed mechanistic and clinical studies will be required and will be more complex than single component pharmaceutical compounds. While it is not a popular idea, it may be beneficial to “throw many wrenches in the works” using biocomplex natural products. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC119947/ and https://www.lifesciencesite.com/lsj/life130616/02_30617lsj130616_12_21.pdf and https://www.tandfonline.com/doi/full/10.1080/09540105.2017.1312292 and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278270/ and https://www.researchgate.net/publication/6589131_Spicing_Up_of_the_Immune_System_by_Curcumin
Although these natural products and their active scaffolds can not be patented or reimbursed by our current medical system, they should be a tool in a toolbox of data driven medical treatment and seem to be helping plug the dam until pharma companies delivers a solution for long term neurological damage from COVID19. A huge percentage of modern pharmaceuticals came from natural products scaffolds and these anecdotal observations should drive data driven pharmaceutical discovery programs for compounds which can treat COVID19 long term effects.
At the moment, there is not a single anti-viral in the public pharmaceutical development process for COVID19 that crosses the blood brain barrier at any significant amount, which may indicate the poor performance of Remdesivir and other drugs promoted by Pharmaceutical companies.. Interestingly, some private groups are mass producing Remdesivir Impurity #4, a compound more than 1000x cheaper to produce due to its simplicity and not in patent. It is not clear the mechanism as it does not have the traditional pharmacophore of its parent molecule, but someone is betting on it enough to mass produce. This compound looks through our molecular modelling like it will cross the blood brain barrier and may be worth taking through the clinical process. GS-441524, a next-generation antiviral produced for Feline Infectious Peritonitis, a neurological viral disease caused by a different coronavirus, looks to have a high safety margin in cats and should be considered for human clinical research.https://www.sciencedirect.com/science/article/pii/S0378113518301603 and https://www.theatlantic.com/science/archive/2020/05/remdesivir-cats/611341/
The current American RNA tests are run at the highest legally allowable PCR amplification cycle maximum, using short primers for non-coding/mutating regions and even have a 90%+ genetic match for Monsanto soybean sequences published! PCR may not be a good tool for diagnosis. The inventor of PCR publicly expresses concern that it should not be used as a diagnostic tool. Korea had rapid success in screening asymptomatic patients using portable CT scanning for detecting lung opacities ,this is not recommended due to the radiation dose required and cost. Detecting lung damage is an excellent screening indicator for asymptomatic, early or dormant infections. The detection of neurotrophic viral RNA or papain like protease in the eye fluid may be the future of screening for SARS-CoV-2 infection and much less invasive. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291693/
Quickly deploying a vaccine would be critical to global health but the timelines are very tight and the margin for error is non-existent. Coronavirus vaccines in animals and humans in the past have been properly designed but still fraught with neurological and immunological issues leading to fatality. Due to the Antibody Dependant Enhancement seen by some front-line researchers, giving a vaccine to a patient who received a false negative test result could lead to immediate neurological damage and most likely fatal events. Clinical trials should be cautious to represent the entire global population of genetic diversity in their patient recruiting -this has never been done before.
Interestingly, blood phototherapy is a good concept to research as it can often require less than 5% of total blood volume, can be done in a few hours in-patient, prodigiously drops the viral load in the blood and shreds the viral RNA in a way where it can be recognized by the ancient innate immune system and immunity generated without requiring a traditional engineered vaccine. If fluid turbulence is induced in this process the immune cells can be activated via mechanical stress.
The mechanism of action of blood phototherapy is not known, as it is counter-intuitive that a small fraction of blood volume can trigger viral drop and immunity in the whole body. It is suspected to involve innate immune response, optical biophysics and the shifting of the dynamic polymer made by the red blood cells coordinating in circulation. The clinical data indicates this is very relevant and there are commercial entities with freedom to operate, IP, etc ready to deploy these systems after clinical research for less than the price of a nice flatscreen TV. Our hemoglobin evolved from chlorophyll and we are beings of energy at the lowest levels. These mechanisms are beyond current medical understanding but it is clear the future of medical treatment will involve optical biophysics. Blood phototherapy may not be a trillion dollar opportunity like global vaccine deployment, but it is grandfathered in as a potential medical intervention and commercial groups are moving forward quickly. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122858/
It should be noted that while many of these questions we are asking and correlations we found go against the grain of what is publicized in the media, our scientific and medical system was not made to move at this speed.
The main purpose of sharing our observations is for the intention that other professionals ask questions outside of the box, review the data, create new tools and techniques and wake up every day and help with global health regardless of the politics and issues of the current medical/scientific consensus system. Our publication is currently in peer review and we hope to commercially and scientifically pursue many of these lines of inquiry.
If we do not start making rapid, data driven decisions not influenced by the political scientific/medical system, the only peer reviewed studies we will have are methods and algorithms for the best way to remove dead bodies from the streets!
It is important with the recent 2020 emergence events of Zika, Hendra, Ebola, Avian Flu and a number of other animal viruses, its clear that naturalistic engineering of the Central Nervous System using forward looking neuropharmacological approaches should be seen as a global human priority, including permanent prophylaxis of the human population against neuroinvasive viral infections.

The author, Nikita K. Alexandrov  holds a degree of Bachelors in Chemistry, Analytical Chemistry Focus  from, Auburn University and a Masters in Business Administration  from University of Alabama at Birmingham.
Nikita Alexandrov is a technology entrepreneur with experience in bioanalytics, enterprise software, aerospace, clean agrotech and pharmacology. Nikita Alexandrov is operating a virtual incubator for technologies related to global health and sustainability in a new world. A large collaborative network is developing AI techniques, new therapeutic concepts for viral pathogens, technology and other solutions. Being a hub of information and connections related to COVID19 solutions, a new, collaborative business landscape model is forming around the solutions required for a sustainable future.
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Feb 05, 2020  2 years ago
Source : Thailand Medical news