Canadian Study Of Herbs That Could Treat COVID-19 Shows That Prunella Vulgaris Extract Inhibits SARS-CoV-2 Cell Entry In Vitro Studies
Source: COVID-19 Herbs-Prunella Vulgaris Sep 01, 2020 5 years, 4 months, 3 weeks, 6 days, 13 hours, 2 minutes ago
A research on herbs that can treat COVID-19 by Canadian researchers from the Department of Medical Microbiology, Faculty of Medicine, University of Manitoba-Canada has shown the extracts from the herb
Prunella Vulgaris is able to inhibit SARS-CoV-2 coronavirus entry into cells in a vitro study.
The research findings are published on a preprint server and are currently being peer-reviewed.
https://www.biorxiv.org/content/10.1101/2020.08.28.270306v1
Prunella Vulgaris is a herb that has been used in Traditional Chinese Medicine (TCM), in Indian Ayurvedic treatments and also in traditional Thai medicine especially in Northern Thailand.
Prunella vulgaris also known as common self-heal, heal-all, woundwort, heart-of-the-earth, carpenter's herb, brownwort and blue curls, is a
herbaceous plant in the genus
Prunella. Prunella vulgaris is a perennial herb native in
Europe,
Asia,
Africa, and
North America, and is common in most temperate climates.
Prunella Vulgaris has been proven to have antiviral activities and is of low toxicity, cheap and readily accessible.
https://pubmed.ncbi.nlm.nih.gov/2161714/
Studies have previously found that a water-soluble substance from the herb Prunella vulgaris exhibited significant antiviral activity against HIV, HSV and Ebola virus.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096947/
https://pubmed.ncbi.nlm.nih.gov/26778707/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114103/
https://pubmed.ncbi.nlm.nih.gov/10588332/
This study showed that Prunella vulgaris extract could block SARS-CoV-2 virus infection and when combined with another compound called Suramin, even had better potency.
The study team demonstrated that an aqueous extract from the herb Prunella vulgaris&nb
sp; displayed potent inhibitory effects on both wild type and mutant (G614) SCoV-2 SP pseudotyped virus (SCoV-2-SP-PVs)-mediated infection.
The 50% inhibitory concentration (IC50) for
Prunella vulgaris extract and SCoV-2-SP-PVs was 30 μg/ml.
To define the mechanisms of their actions, the researchers demonstrated that both
Prunella vulgaris extract was able to directly interrupt SCoV-2–SP binding to its receptor ACE2 and block the viral entry step.
Importantly, the study results also showed that Prunella vulgaris extract can efficiently reduce levels of cytopathic effect caused by SARS-CoV-2 virus (hCoV-19/Canada/ON-VIDO-01/2020) infection in Vero cells.
Results revealed that the presence of Prunella vulgaris extract was able to specifically target and significantly reduce the SARS-CoV2-SP-ACE2 interaction.
Overall, the study provides evidence that Prunella vulgaris extract has anti-SARS-CoV-2 activity and may be developed as a novel antiviral approach against SARS-CoV-2 infection.
The study also showed that Prunella vulgaris extract could be used as an adjuvant to enhance antibody neutralizing activity.
Thailand Medical News has developed a patented therapeutic tea blend that also contains Prunella vulgaris along with 24 other researched herbs that is particularly ideal during this COVID-19 Era.
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For more details on those teas, refer to:
https://www.thailandmedical.news/news/new-therapeutic-teas-
For more on
COVID-19 Herbs, keep on logging to Thailand Medical News.
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