BREAKING! COVID-19 News: Study Shows That Most Infected With SARS-CoV-2 Likely To Develop Dyslipidemia And Sebum Lipodome Changes Leading To Skin-Aging!
A new study led by British researchers from University Of Surrey along with scientist from University of Manchester, Aston University, University of Leicester and the Frimley Health NHS Trust Hospital have found that most individuals infected with the SARS-CoV-2 coronavirus that causes the COVID-19 disease are likely to develop dyslipidemia and changes in their sebum lipodomes that can also lead to premature aging of the skin in the long term.
The study team explored the potential for using sebum, collected via swabbing of a patient's skin, as a novel sampling matrix to fulfill requirements for diagnosis and prognosis. In this pilot study, sebum samples were collected from 67 hospitalized patients (30 PCR positive and 37 PCR negative).
All COVID-19 infected patients had various conditions of the disease ie mild, moderate to severe.
Detailed lipidomics analysis was carried out using liquid chromatography mass spectrometry.
Total fatty acid derivative levels were found to be depressed in COVID-19 positive participants, indicative of dyslipidemia
Orthogonal Partial Least Squares-Discriminant Analysis (OPLS-DA) modelling showed promising separation of COVID-19 positive and negative participants when comorbidities and medication were controlled for.
The study findings were published on a preprint server and are currently being peer-reviewed. https://www.medrxiv.org/content/10.1101/2020.09.29.20203745v1
As the SARS-CoV-2 coronavirus requiring lipids for reproduction, COVID-19 can be expected to disrupt the lipidome. https://www.mdpi.com/1422-0067/21/10/35441
Evidence of dysregulated lipidomes have recently been observed in patients with COVID-19 in other published studies as well. https://pubs.rsc.org/en/Content/ArticleLanding/2020/AN/D0AN01074J#!divAbstract
This phenomenon of dyslipidemia and sebum lipodome changes is also seen in HIV patients. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154840/
As a result of various lipid metabolic pathways being disrupted, certain lipids might get upregulated while some are downregulated.
It should be noted that certain of this disruptions in the lipid metabolism can result in serious cardiovascular conditions.
On the other hand changes in the sebum lipodomes can cause skin issues and also premature skin-aging
Dyslipidemia and changes in the sebum lipodomes can also cause a variety of dermatological problems includin
g psoriasis besides premature skin aging. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677465/
Interestingly this study was conducted to asssess these sebum changes as a form of COVID-19 detection.
As canines are very sensitive to human skin and sebum and are being trained canines to detect COVID-19 infected individuals, the study was conducted to also evaluate if there were truly any sebum lipodome changes taking place in infected COVID-19 patients.
Given that sebum sampling is rapid and non-invasive, this work may offer the potential for diagnostic and prognostic testing for COVID-19.
Recovered' COVID-19 patients, whether symptomatic or asymptomatic developing any dermatological issues should consult a skin specialists or dermatologist immediately.
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