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BREAKING NEWS
  Oct 17, 2018

Relapsed/Refractory Follicular Lymphoma Causes

Follicular lymphoma (FL) is an indolent tumor of the lymphatic system, which may often remain inactive for years before undergoing transformation into an aggressive tumor.

After treatment, a high percentage of patients fail to respond, and these tumors are categorized as refractory lymphomas. Some respond with an initial positive change, but then develop signs of recurrent tumor, called relapsed follicular lymphoma.

What causes patients to enter either of these categories is still unknown, but older people above the age of 60 years at the age of diagnosis are known to have a much higher risk of relapse and transformation. Other possible factors include advanced stage at diagnosis, large tumors, the involvement of the bone marrow and other symptoms, among other blood parameters. These have been incorporated into the FL International Prognostic Index (FLIPI), which was widely used to classify patients at risk of relapsed or refractory FL. With the advent of the monoclonal antibody rituximab, which has proved effective in the treatment of FL, the revised version, FLIPI 2, is now in use, which uses other parameters such a