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  Oct 17, 2018

Relapsed-Refractory Follicular Lymphoma and Personalized Medicine

Follicular lymphoma is a personalized disease in itself, which makes it difficult to apply averages to its treatment. It is established that it occurs far more frequently in the elderly.

This is thought to be due to biological differences in the tumor cells occurring in the elderly compared to younger patients.

These may include various cytogenetic modifications, immune factors including variations in the types and functional status of various immune cells, such as macrophages and T-cells of different classes in the non-malignant parts of the tumor.

The rate at which these tumors transform into more aggressive types is also largely unpredictable, as is their likelihood of relapse or their initial response to chemotherapy or immunotherapy.

Even so, it is known today that even in the higher-risk elderly patients, a regimen of appropriately dosed drugs can help them achieve remission rates comparable to those found in younger age groups. This requires an initial complete evaluation of elderly patients who have r