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  Sep 27, 2018
  Sep 27, 2018
Venlafaxine hydrochloride
Consumer Medicine Information

What is in this leaflet

This leaflet answers some common questions about Altven.
It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the risks of you taking Altven against the benefits it is expected to have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may need to read it again.

What Altven is used for

What it does

Altven is used in the treatment and prevention of relapse of depression. It is also used in the treatment of panic attacks and anxiety, including avoidance or fear of social situations.
Depression can affect your whole body and may cause emotional and physical symptoms such as feeling low in spirit, being unable to enjoy life, poor appetite or overeating, disturbed sleep, loss of sex drive, lack of energy and feeling guilty over nothing.
Excessive anxiety is a condition in which you feel constantly and uncontrollably worried and distressed. It may also make you feel irritable, and cause difficulty in thinking and sleeping. Other common symptoms associated with anxiety may include a dry mouth, a lump in the throat, cold clammy hands, diarrhoea and nausea.
Depression and anxiety are treatable illnesses. Anxiety or tension associated with the normal stress of everyday life usually does not require treatment with medicines.
Ask your doctor if you have any questions about why this medicine has been prescribed for you.
Your doctor may have prescribed it for another reason.

How it works

Altven contains the active ingredient called venlafaxine hydrochloride. It belongs to a class of medications for depression and anxiety, called Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs).
Serotonin and noradrenaline are chemical messengers that allow certain nerves in the brain to work. Altven capsules increase the level of these two messengers. Experts think this is how it helps to restore your feeling of wellness.
Altven is not addictive.
It is available only with a doctor's prescription.

Use in Children

Do not give Altven to children or adolescents under 18 years of age.
The safety and effectiveness of Altven in this age group have not been established.

Before you take Altven

When you must not take it

Do not take Altven if you are taking other medications for depression known as monoamine oxidase inhibitors, even if you have stopped taking them now, but have taken them within the last 14 days.
Do not take Altven if you are allergic to it or to any of the ingredients listed at the end of this leaflet.
Symptoms of an allergic reaction may include:
Rash, itching or hives on the skin
Swelling of the face, lips, tongue, throat or other parts of the body
Shortness of breath, wheezing or troubled breathing; difficulty swallowing.
Do not take this medicine after the expiry date (EXP) printed on the pack or if the packaging is torn or shows signs of tampering.
If it has expired or is damaged, return it to your pharmacist for disposal.
If you are not sure whether you should start taking this medicine, talk to your doctor.

Before you start to take it

Tell your doctor or pharmacist if you have allergies to any other medicines, foods, preservatives or dyes.
Tell your doctor or pharmacist if you are pregnant or intend to become pregnant.
Altven is not recommended for use during pregnancy. Your doctor will discuss the risks and benefits of using this medicine if you are pregnant. One of these risks is that newborn babies, whose mothers have been taking Altven in the last few months of pregnancy, may experience problems soon after delivery, including breathing difficulties, seizures and lack of oxygen in their blood.
Tell your doctor or pharmacist if you are breast-feeding or planning to breast-feed.
Altven passes into breast milk and there is a possibility that the breast-fed baby may be affected. For this reason, the use of Altven is not recommended in breast-feeding women.
Tell your doctor if you have or have had any of the following medical conditions:
A history of fits (seizures or convulsions)
A personal history or family history of bipolar disorder
A history of aggression
A history of restlessness or difficulty sitting still
Blood pressure problems
Glaucoma (increased pressure in the eye)
A tendency to bleed more than normal or you are taking medicines to prevent blood clots
Raised cholesterol levels or you are taking medicines to lower cholesterol
Problems with your kidneys or liver
Problems with your heart, especially conditions causing irregular heartbeats.
Your doctor may wish to do some heart tests such as an electrocardiogram (ECG) or blood tests during treatment with Altven.
Tell your doctor if you plan to have surgery.
If you have not told your doctor about any of the above, tell them before you start taking Altven.

Taking other medicines

Tell your doctor or pharmacist if you take any other medicines, including:
all prescription medicines
medicines for weight loss
all medicines, vitamins, herbal supplements or natural therapies you buy without a prescription from a pharmacy, supermarket, naturopath or health food shop.
Do not start to take any other medicine while you are taking Altven, unless it is prescribed or approved by your doctor.
Some medicines may interfere with Altven, or Altven may interfere with these medicines. These include:
Medications for depression known as monoamine oxidase inhibitors (such as moclobemide, linezolid, phenelzine and tranylcypromine), even if you have stopped taking them now, but have taken them within the last 14 days. Your doctor or pharmacist can tell you what to do if you are taking any of these medicines
Any other medications for depression, anxiety, obsessive-compulsive disorder or premenstrual dysphoric disorder, including St John's wort
Medicines for treating mental disorders such as haloperidol, risperidone, lithium or clozapine
Tramadol, fentanyl, tapentadol, pethidine and methadone used to treat strong pain
Medicines used to treat Attention Deficit Hyperactivity Disorder (ADHD) such as dexamphetamine and lisdexamphetamine
Cimetidine for reflux and stomach ulcers
Triptans used to treat migraine
Amiodarone or quinidine used to treat irregular heartbeats.
Your doctor may do some heart tests such as an electrocardiogram (ECG) or blood tests if you are using either of these medicines whilst taking Altven:
Metoprolol for high blood pressure or angina
Medicines used to prevent blood clotting such as anti-coagulants and platelet inhibitors
Indinavir for viral infections
Antibiotics such as erythromycin and linezolid for bacterial infections
Ketoconazole or fluconazole for fungal infections.
You may need to use different amounts of your medicine, or you may need to take different medicines. Your doctor will advise you.
Your doctor and pharmacist have more information on medicines to be careful with or avoid while this medicine.

How to take Altven

Follow all directions given to you by your doctor or pharmacist carefully.
They may differ from the information contained in this leaflet.
If you do not understand the instructions on the box, ask your doctor or pharmacist for help.

How much to take

Your doctor will tell you how many capsules you need to take each day. This may depend on your age, your condition and whether or not you are taking any other medicines.
Depression and Anxiety
The usual starting dose is 75 mg taken once daily. After 2 weeks, your doctor may increase the dose to 150 mg a day.
Panic attacks
The usual starting dose is 37.5 mg taken once daily for the first 4 to 7 days, then increased to 75 mg taken once daily.
Do not change your dose unless your doctor tells you to.
If you have kidney or liver problems, you may need a lower dose of Altven.
If you have heart problems your doctor may first do some blood tests or heart tests such as an electrocardiogram (ECG) before increasing your dose of Altven.

How to take it

Swallow the capsules whole with a glass of water or other non-alcoholic liquid.
Do not divide, crush, chew or dissolve the capsules in water.
Do not be concerned if you see small white granules or balls in your stools after taking Altven.
Inside Altven capsules are spheroids or small white balls that contain the venlafaxine active ingredient. These spheroids are released from the capsule into your gastrointestinal tract. As the spheroids travel the length of your gastrointestinal tract, venlafaxine is slowly released. The spheroid 'shell' remains undissolved and is eliminated in your stools. Therefore, even though, you may see spheroids in your stools, your dose of venlafaxine has been absorbed.

When to take it

Take your medicine once daily with food, at approximately the same time each day.
This could be either in the morning or in the evening.
Taking it at the same time each day will have the best effect. It will also help you remember when to take it.
Avoid drinking alcohol while you are taking Altven.

How long to take it

Continue taking your medicine for as long as your doctor tells you.
Although you may begin to feel better after two weeks, it may take several weeks before you feel much better. It is important to give Altven time to work.
This medicine helps to control your condition, but does not cure it. It is important to keep taking your medicine even if you feel well.

If you forget to take it

If it is less than 12 hours until your next dose, skip the dose you missed and then take your next dose when you are meant to. Otherwise, take it as soon as you remember, and then go back to taking as you would normally.
Do not take a double dose to make up for the dose you missed.
This may increase the chance of you getting an unwanted side effect.
If you are not sure what to do, ask your doctor or pharmacist.
If you have trouble remembering to take your medicine, ask your pharmacist for some hints.

If you take too much (overdose)

Immediately telephone your doctor or Poisons Information Centre (Tel 13 11 26) for advice, or go to Accident and Emergency at your nearest hospital if you think that you or anyone else may have taken too much Altven.
Do this even if there are no signs of discomfort or poisoning.
You may need urgent medical attention.
If you take too many Altven capsules you may:
Feel sleepy
Have an increased heart rate or changes in heart rhythm
Have a seizure (fits)
Have breathing difficulties
Become unconscious
Have dilated pupils.
Keep the telephone number for these places handy whilst taking any medications.

While you are taking Altven

Things you must do

Visit your doctor regularly for a check up so that your progress can be checked.
Your doctor may do some tests (such as an electrocardiogram (ECG) or blood tests) from time to time to make sure the medicine is working and to prevent unwanted side effects.
Always discuss any questions you have about Altven capsules with your doctor.
If you are going to have surgery, tell your doctor that you are taking this medicine.
Some agents used to assist your doctor during surgery may interact with Altven leading to unwanted side effects.
If you are about to have any urine tests, tell your doctor that you are taking this medicine.
It may interfere with the results of some tests.
Take Altven capsules as your doctor has prescribed.
Keep enough Altven capsules to last weekends and holidays.
This medicine helps to control your condition, but does not cure it. It is important to keep taking your medicine even if you feel well.
Tell any other doctors, dentists, and pharmacists who treat you that you are taking this medicine.
Watch carefully for signs that your depression or anxiety is getting worse, especially in the first few weeks of treatment, or if your dose has changed.
Sometimes people with depression can experience a worsening of their depressive symptoms. This can happen even when taking an antidepressant.
Information from clinical trials has suggested that children, adolescents and young adults (18-24 years), particularly those with depression, may be at increased risk of suicidal behaviour (including suicide attempts) when treated with Altven, especially during initial treatment.
Tell your doctor immediately if you experience any of the following symptoms, especially if they are severe, you have not had these symptoms before or they happen very suddenly:
Anxiety or agitation
Panic attacks
Difficulty sleeping
Hostility or impulsiveness
Overactivity or uninhibited behaviour
Other unusual changes in behaviour
Thoughts of suicide.
Tell your doctor immediately if you have any thoughts about suicide or doing harm to yourself.

Warning signs of suicide

If you or someone you know is showing the following warning signs, either contact your doctor or a mental health advisor right away or go to the nearest hospital for treatment.
All thoughts or talk about suicide or violence are serious.
Thoughts or talk about death or suicide
Thoughts or talk about self-harm or doing harm to others
Any recent attempts of self-harm
An increase in aggressive behaviour, irritability or agitation.

Things to be careful of

Be careful driving or operating dangerous machinery until you know how it affects you.
Altven capsules may make you feel drowsy.
If you are feeling drowsy or are uncoordinated, be careful that you do not fall over.
Altven, like other medicines in this class, may increase your risk of bone fracture.

Things you must not do

Do not suddenly stop taking Altven or lower the dose if you have been taking it for some time.
If possible, your doctor will gradually reduce the amount you take each day before stopping the medicine completely.
If you stop taking it suddenly, your condition may worsen or you may have unwanted side effects such as:
Nausea and vomiting
Confusion and agitation
Loss of appetite
Flu-like symptoms
Impaired coordination and balance
Tingling or numbness of the hands and feet.
Slowly reducing the amount of Altven being taken reduces the possibility of these effects occurring.
Some of these symptoms may impair driving, or the operation of dangerous machinery. Avoid these activities if you experience these symptoms.
Do not give this medicine to anyone else even if they have the same condition as you.

Side effects

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Altven.
All medicines can have side effects. Sometimes they are serious; often they are not. You may need medical attention if you get some of the side effects.
It can be difficult to tell whether side effects are the result of taking this medicine, effects of your condition, or side effects of other medicines you may be taking. For this reason it is important to tell your doctor of any change in your condition.
Do not be alarmed by the list of side effects.
You may not experience any of them.
Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor if...

Tell your doctor or pharmacist if you notice any of the following and they worry you:
Stomach, bowel or urinary tract problems:
Nausea or vomiting
Loss of appetite
Difficulty passing urine, passing urine more frequently, or urinary incontinence
Changes in your behaviour:
Difficulty sleeping or abnormal dreams
Sexual function problems such as delayed ejaculation, problems with erection, decreased sex drive or difficulties achieving orgasm
Teeth grinding
Impaired coordination and balance
Difficulty thinking or working because of:
Feeling sedated or drowsy
Fainting or dizziness after standing up
Restlessness or difficulty sitting still
Rapid heart beat
Heavy or irregular menstrual periods
Hot flushes
Hair loss
Weight loss
Weight gain
Flow of milk in women who are not breastfeeding
Blurred vision
Ringing in the ears
Altered taste
Dry mouth.

Tell your doctor as soon as possible if...

Tell your doctor as soon as possible if you notice any of the following:
Muscle tremors, spasms, twitching, jerky movements or sustained muscle contractions
Abnormal facial movements such as tongue thrusting, repetitive chewing, jaw swinging, or grimacing
A feeling of apathy or not caring about things
Unusually overactive
Changes in muscle tone, muscle weakness or fatigue
Numbness or pins and needles.
Problems with breathing, shortness of breath
Bleeding or bruising more easily than normal
Sensitivity to sunlight.

Go to hospital if...

Tell your doctor immediately, or go to Accident and Emergency at your nearest hospital if you notice any of the following:
Fits or seizures, which may be accompanied by a sudden fever
Signs of allergy such as rash or hives, swelling of the face, lips, tongue or throat, wheezing or difficulty breathing or swallowing
Symptoms of sudden fever with sweating, rapid heartbeat and muscle stiffness, which may lead to loss of consciousness
Palpitations, shortness of breath, intense chest pain, or irregular heartbeats
Dark, red or cola-coloured urine, muscle weakness and tenderness, stiffness or aching
Stomach pain, yellowing of the skin, nausea, fever, clammy skin and sweating
Yellowing of the skin or eyeballs, fever, fatigue, loss of appetite, dark coloured urine or light coloured bowel movements
A severe skin reaction with painful red areas and large blisters, accompanied by fever and chills, aching muscles and generally feeling unwell
Symptoms of a high fever, agitation, confusion, trembling and abrupt contractions of muscles
Signs of an infection such as severe chills, fever, sore throat and mouth ulcers
Black sticky bowel motions or bloody diarrhoea.
These symptoms are usually rare but may be serious and need urgent medical attention.
Tell your doctor or pharmacist if you notice anything else that is making you feel unwell.
Other side effects not listed above may also occur in some people. Some of these side effects (for example, increase in blood pressure or blood cholesterol) can only be found when your doctor does tests from time to time to check your progress.

After taking Altven


Keep your capsules in their blister pack until it is time to take them.
If you take the capsules out of the blister pack they may not keep well.
Keep Altven capsules in a cool dry place where the temperature stays below 30°C.
Do not store Altven capsules or any other medicine in the bathroom or near a sink. Do not leave it in the car or on windowsills.
Heat and dampness can destroy some medicines.
Keep it where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.


If your doctor tells you to stop taking this medicine or the expiry date has passed, ask your pharmacist what to do with any medicine that is left over.

Product description

What it looks like

There are three strengths of Altven capsules:
Altven 37.5 mg capsules are grey and peach in colour
Altven 75 mg capsules are opaque peach in colour
Altven 150 mg capsules are opaque dark orange in colour.
Each capsule is printed with a "W" and the capsule strength.
Each blister pack contains 28 capsules.


Altven contains 37.5 mg, 75 mg and 150 mg venlafaxine hydrochloride as the active ingredient.
It also contains:
Iron oxide yellow CI 77492
Iron oxide red CI 77491
Ethyl cellulose
Talc, purified
Titanium dioxide
Red ink Opacode S-1-15094/S-1-15095 (37.5 mg and 75 mg only)
White ink TekPrint SB-0007P (150 mg only)
Iron oxide black CI 77499 (37.5 mg only).
Altven does not contain gluten, sucrose, tartrazine or any other azo dyes.