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  Sep 27, 2018
  Sep 27, 2018
Consumer Medicine Information

What is in this leaflet

This leaflet answers some common questions about Afinitor.
It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.
The information in this leaflet was last updated on the date listed on the final page. More recent information on the medicine may be available.
You should ensure that you speak to your pharmacist or doctor to obtain the most up to date information on the medicine. You can also download the most up to date leaflet from
Those updates may contain important information about the medicine and its use of which you should be aware.
All medicines have risks and benefits. Your doctor has weighed the risks of you taking Afinitor against the benefits they expect it will have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may need to read it again.

What Afinitor is used for

Afinitor is used in the treatment of renal cell carcinoma, a type of kidney cancer; neuroendocrine tumours (NETs), a type of cancer located in the stomach and intestine, lung or pancreas; tuberous sclerosis complex (TSC) with angiomyolipoma of the kidney (a kidney tumour) not requiring immediate surgery; TSC with subependymal giant cell astrocytoma (sometimes called 'SEGA'), a specific type of brain tumour not requiring immediate surgery or certain types of seizures (epilepsy) associated with TSC in children and adults.
Afinitor is also used in the treatment of hormone receptor-positive HER2 negative advanced breast cancer in postmenopausal women, in conjunction with exemestane after failure of letrozole or anastrozole.
It is only used in patients whose tumour has tested negative to HER2.
Everolimus is the active substance in Afinitor.
Treatment of kidney cancer
Afinitor stops the cancer from making new cells and cuts off the blood supply. This slows the growth and spread of the cancer.
Treatment of NETs
Afinitor is used to control the growth of these tumours located in the stomach and intestine, lung or pancreas.
Treatment of SEGA
Afinitor reduces the size of brain tumours (SEGA) that are caused by a genetic disorder called tuberous sclerosis. This may stop the tumours from causing problems as they grow, such as hydrocephalus (excessive accumulation of fluid within the brain).
Treatment of TSC with angiomyolipoma of the kidney
Afinitor may reduce the size of angiomyolipoma of the kidney that is associated with a genetic disorder called TSC. This may lower the risk of the tumour(s) causing bleeding complications and may help to preserve kidney function.
Treatment of TSC with seizures
Afinitor may reduce the frequen