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Source: COVID-19 DRUGS  Apr 18, 2020  2 years ago
Study Published In The American Journal Of Tropical Medicine Advocates Further Research Into Ivermectin For COVID-19 Treatment As It Could Emerge As A Good Drug Candidate
Study Published In The American Journal Of Tropical Medicine Advocates Further Research Into Ivermectin For COVID-19 Treatment As It Could Emerge As A Good Drug Candidate
Source: COVID-19 DRUGS  Apr 18, 2020  2 years ago
COVID-19 Drugs: Ivermectin is gaining more attention as a possible drug candidate as it is an already approved drug for the treatment of parasites and also various virus causing diseases. It has already demonstrated to possess relevant antiviral properties.

More than 2.5 billion doses of the drugs have been used by humans in the last 30 years to treat malaria, dengue fever and even the  Zika virus besides it main role as an anti-parasitic drug.
The new study published in the American Journal of Tropical Medicine and Hygiene advocates more research and clinical trials for Ivermectin to be used against the COVID-19 disease. https://www.ajtmh.org/docserver/fulltext/10.4269/ajtmh.20-0271/tpmd200271.pdf?expires=1587144119&id=id&accname=guest&checksum=640FF9040ACCC6FE790A238A63D97520
Ivermectin has been proven to inhibit the in vitro replication of some positive, single-stranded RNA viruses dues to its antiviral properties. Studies have shown that it has been effective against the RNA viruses, namely, dengue virus (DNV), Zika virus, yellow fever virus, and others.(please see references at the end of the article)
Despite some raised concerns by certain unqualified “researchers” who were busy trying to lobby the dangerous drugs chloroquine and hydroxychloroquine and certain ‘big pharma’ candidates while raising dosing concerns  that were based on not proper comparisons on the initial invitro study and the required dosing required in humans, certain private trials and offical trials underway are showing exteremely positive results.

The concerns were based on mere extrapolation of the amounts used in the vitro studies without taking into considerations the way the drugs reacts in human bodies and  simply jumping into the conclusion that only mega doses of ivermectin (which can be toxic at such levels as with any drug) could be effective in eradicating the SARS-CoV-2 virus which was not true.
The spotlight on Ivermectin was brought into the spotlight by Australian researchers from Monash University who demonstrated its efficacy against the SARS-CoV-2 coronavirus in vitro studies. https://www.thailandmedical.news/news/must-read-covid-19-drug-research-ivermectin-might-emerge-as-one-of-the-most-suitable-drug-candidates-for-covid-19
The initial study was published in the Journal On Antiviral Research
There has already been a few animal studies and also human trials conducted so far which has had positive results and we would be covering on that in the next few days as the reports gets published.
Compared to drug candidates like remidesivir, favipiravir and other antivirals, Ivermec tin is less toxic and and when compared to the dangerous drugs that have no known efficacy towards treating COVID-19 like chloroquine and hydroxychloroquine, Ivermectin seems to be one of the most promising drug candidates.
However a caution has to be made as many ignorant individuals are rushing out and acquiring Ivermectin meant for livestock and animals to self-medicate. This is extremely dangerous and can be fatal as medications meant for animals and veterinary use is different from that for those for humans.
Furthermore no one should ever self-medicate or consume any drugs mentioned in researches etc without the supervision of a medical doctor or qualified healthcare professional.
Ivermection for humans is sold under the brandname Vermectin and is not easily available and is currently expensive.
For more developments about Ivermectin and also about the latest on COVID-19 drugs research, keep logging on to Thailand Medical News.
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Additional researches:
-Tay MY, Fraser JE, Chan WK, Moreland NJ, Rathore AP, Wang C Vasudevan SG, Jans DA, 2013. Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all
-DENV serotypes by the inhibitor Ivermectin. Antiviral Res 99: 301–306. 4. Yang SNY, Atkinson SC, Wang C, Lee A, Bogoyevitch MA, Borg NA, Jans DA, 2020. The broad spectrum antiviral ivermectin targets the host nuclear transport importin alpha/beta1 heterodimer. Antiviral Res 177: 104760.
 -Wagstaff KM, Sivakumaran H, Heaton SM, Harrich D, Jans DA, 2012. Ivermectin is a specific inhibitor of importin alpha/betamediated nuclear import able to inhibit replication of HIV-1 and dengue virus. Biochem J 443: 851–856.
-Barrows NJ et al., 2016. A screen of FDA-approved drugs for inhibitors of Zika virus infection. Cell Host Microbe 20: 259–270.
-Varghese FS, Kaukinen P, Glasker S, Bespalov M, Hanski L, Wennerberg K K ¨ummerer BM, Ahola T 2016. Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses. Antiviral Res 126: 117–124.
 -Mastrangelo E et al., 2012. Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug. J Antimicrob Chemother 67: 1884–1894.
 -Lee YJ, Lee C, 2016. Ivermectin inhibits porcine reproductive and respiratory syndrome virus in cultured porcine alveolar macrophages. Arch Virol 161: 257–268


Feb 05, 2020  2 years ago
Source : Thailand Medical news