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Source: Covid-19 Diagnostics  Mar 24, 2020  6 days ago
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Source: Covid-19 Diagnostics  Mar 24, 2020  6 days ago
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British-based Iceni Diagnostics is developing a new approach that identifies the SARS-CoV-2 coronavirus, not by its genetic code, which can mutate, but by using its reliance on chains of sugars which are constant and unchangeable. The existing prototype product for influenza can detect the virus in less than 20 minutes and could be adapted to identify other pathogens such as the novel coronavirus.

Coronaviruses typically invade the body through cells in the respiratory tract. These cells are covered in a coat of sugar chains, known as glycans, which are used to recognize beneficial substances. Viruses can utilize these glycans as part of the infection process. This process can also be used in reverse to identify the virus in saliva or nasal fluids.

Dr Rob Field, a leading biotech professor and an expert in glycan science and Director of the Manchester Institute of Biotechnology, is the co-founder of Iceni Diagnostics, a biotechnology company based on the Norwich Research Park. The company has developed this diagnostic technique that uses an artificial glycan receptor to capture the virus.

Dr Field told Thailand Medical News, “Right now, everybody is talking about a vaccine for coronavirus but vaccine development, validation, safety-testing, manufacture, regulatory approval and deployment is a time-consuming process. A low-cost, easy to use screening test that can be performed at the point of care is an ideal way to limit initial disease transmission in the country or location of origin.”

He further added, “Current Covid-19 tests are largely based on PCR (polymerase chain reaction) that requires a laboratory setting for analysis and relies on prior knowledge of the viral genetic code. This code can change as the SARS-CoV-2 virus evolves, limiting the effectiveness of the test.”

Further commenting, he said, “The Iceni Diagnostics approach uses glycan recognition, which is unaffected by seasonal variation in the genetic code, and can be offered as a handheld home or field-based test.”

The company has already developed a series of prototype products that can specifically detect pathogens such as Norovirus and different strains of influenza in less than 20 minutes. The most advanced product, for equine influenza, is performing well in early stage clinical trials.

The new hand-held device uses lateral flow  like a home pregnancy test  to give a simple yes/no answer. It requires no refrigeration and no training, meaning the test is usable in any location, by any person, in order to detect flu or other pathogens.

At the moment, the current Iceni Diagnostics products detect a single virus. However, the next generation of diagnostics aim to enable the detection and discrimination of a series of pathogens that give rise to similar symptoms. This would enable, for example, a distinction between flu and COVID-19 in a single sample. This increases the versatility and robustness of the diagnosis.

Furthermore the way the SARS-2 Coronavirus interacts with its glycan receptor makes it seasonally consistent, so, even if the virus genetic code mutates, it will still be detected  meaning the test could remain effective indefinitely.

Dr Field comments that the device holds huge promise for changing the way we manage global Covid-19 disease which is fast changing day by day due to the mutations and emerging strains “This new approach, which is based on host-pathogen glycan recognition could potentially result in a more universal detection technique, crucial in early diagnostics of outbreaks.”

Reference: https://www.icenidiagnostics.com/

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