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Source: Lipids And COVID-19   Oct 11, 2021  2 years, 6 months, 1 week, 1 day, 5 hours, 35 minutes ago

University of Pennsylvania Study Shows That Lipids Pay A Critical Role In SARS-CoV-2 Replication And Human Immune Response

University of Pennsylvania Study Shows That Lipids Pay A Critical Role In SARS-CoV-2 Replication And Human Immune Response
Source: Lipids And COVID-19   Oct 11, 2021  2 years, 6 months, 1 week, 1 day, 5 hours, 35 minutes ago
A new study by researchers from the University of Pennsylvania showed that that lipids pay a critical role in SARS-CoV-2 replication and human immune response.

 
According to the study abstract, “Lipids play essential roles in the viral life cycle. The lipid composition of cell membranes can influence viral entry by mediating fusion or affecting receptor conformation. Upon infection, viruses can reprogram cellular metabolism to remodel lipid membranes and fuel the production of new virions. Further, several classes of lipid mediators, including eicosanoids and sphingolipids, can regulate the host immune response to viral infection.”
 
The study team summarize the existing literature on the mechanisms through which these lipid mediators may regulate viral burden in COVID-19. They also defined the gaps in knowledge and identify the core areas in which lipids offer therapeutic promise for SARS-CoV-2.
 
The study findings were published in the peer review Journal of Lipid Research. https://www.jlr.org/article/S0022-2275(21)00111-5/fulltext
 
The SARS-CoV-2 coronavirus that emerged in Wuhan, China, in mid-December 2019, has infected over 238 million worldwide and caused the deaths of over 4.86 million individuals globally. This has led to intensive research into the pa