Covid-19 Research Shows That Hypertension and Diabetes Delay Viral Clearance In Infected Patients And Also Cortisone Usage
: A new study by researchers from the Zhongnan Hospital in Wuhan lead by Dr Chen Xiaoping has showed that Covid-19 patients with underlying disease like Diabetes and Hypertension have a worse prognosis once infected with Covid-19. https://www.medrxiv.org/content/10.1101/2020.03.22.20040774v1.full.pdf+html
The study involved 106 patients from Zhongnan Hospital between January 5th
to February 25th
. The study involved looking at underlying diseases that contribute the most to aggravate the conditions of COVID-19 patients. SARS-CoV-2 viral clearance is a golden standard for defining the recovery of COVID-19 infections.
The study found that increasing age, male gender, and angiotensin-converting enzyme 2 (ACE2) associated factors (including hypertension, diabetes, and cardiovascular diseases) adversely affected the viral clearance.
Furthermore, analysis by a random forest survival model pointed out hypertension, cortisone treatment, gender, and age as the four most important variables.
The study concluded that patients at old age, males, and/or having diseases associated with high expression of ACE2 will have worse prognosis.
COVID-19 most often displays as fever, cough and mild fatigue, sometimes also dyspnea, 73 myalgia and severe anorexia, and may develop into critical respiratory failure that sometimes becomes fatal.
It has been shown that severe COVID-19 often occurred in patients with diabetes, hypertension or other comorbidities. In COVID-19 patients with underlying diseases, a very high case fatality rate (73.3%) has been observed.
However, how these comorbidities affect the COVID-19 prognosis is not yet understood. Potential factors might be that these comorbidities directly accelerate the damage of target tissues or that they favour the virus life-cycle during a SARS-CoV-2 infection.
The study showed was found that chronic diseases including diabetes and hypertension deteriorate the clearance of SARS-CoV-2 from the body.
It must also be noted that the usage of cortisone had unexpectedly a negative effect on the process of viral clearance, although cortisone was commonly used in the SARS patients. It is possible that cortisone was targeted at particularly severe cases, which may have confounded the results.
Compared to SARS, the outcome of using corticosteroids in COVID-19 patients is still unclear. Given that corticosteroids as immune-modulators that can decline circulating specific B- and T-cell subsets, the researchers’ modelling, show that the usage of cortisone would not be recommended.
An earlier Scottish study published in the Lancet also warned against the usage of steroids for Covid-19 treatments.https://www.thailandmedical.news/news/warning-scottish-researchers-warn-against-using-steroids-for-any-treatment-protocols-for-coronavirus-as-it-could-do-more-harm
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