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Source: COVID-19 Herbs  Feb 01, 2021  3 years, 2 months, 2 weeks, 2 days, 7 hours, 56 minutes ago

COVID-19 Herbs: Saudi Arabia Study Demonstrates Possible Use Of Echinacea and St. John's Wort As Therapeutic Agents Against COVID-19

COVID-19 Herbs: Saudi Arabia Study Demonstrates Possible Use Of Echinacea and St. John's Wort As Therapeutic Agents Against COVID-19
Source: COVID-19 Herbs  Feb 01, 2021  3 years, 2 months, 2 weeks, 2 days, 7 hours, 56 minutes ago
COVID-19 Herbs: Scientists from King Fahd Medical Research Center at King Abdulaziz University in a new study have demonstrated the antiviral effects of two medicinal herbs: Hypericum perforatum also called St. John's Wort and Echinacea or Purple Cone Flower against the SARS-CoV-2 coronavirus, the pathogen that causes COVID-19.the study showed that each herb as well as the two combined, exerted inhibitory and virucidal effects on SARS-CoV-2-infected Vero E6 cells.


 
Importantly the effects were most potent when cells were treated with H. perforatum. A combination of the two herbs was the second most effective, and treatment with Echinacea alone was the least effective.
 
In this study and based on the previous reviews, Hypericum perforatum (St. John’s Wort) and Echinacea were tested in vitro using Vero E6 cells for their anti-viral effects against the newly identified SARS-CoV-2 through its infectious cycle from 0 to 48 hours post infection. The hypericin (0.9 mg) of H. perforatum and the different parts (roots, seeds, aerial) of two types of Echinacea species (Echinacea purpurea and Echinacea angustifolia) were examined for their efficacy in certain concentration and under light-dependent anti-viral activities to measure the inhibition of the SARS-CoV-2 mRNA expression of RNA-dependent RNA polymerase (RdRP) gene and the viral load with quantitative real-time polymerase chain reaction (qRT-PCR), and to assess the neutralization of the SARS-CoV-2 spike receptor binding on cell culture assay. Interestingly, the mixture (H.E.) of 100 mg/mL of H. perforatum and Echinacea was tested too on SARS-CoV-2 and showed crucial anti-viral activity competing H. perforatum then Echinacea effects as anti-viral treatments.
 
The study findings were published on a preprint server and are currently being peer reviewed. https://www.biorxiv.org/content/10.1101/2021.01.11.426295v1
 
Dr Leena Hussein Bajrai and colleagues from King Abdulaziz University in Jeddah recommend that clinical trials be initiated to investigate the herbs as potential treatments for SARS-CoV-2 infection.
 
Thailand Medical news had already mentioned about the possibility of using Echinacea as both a prophylaxis and also as a therapeutic agent to treat COVID-19 as early as March 2020. https://www.thailandmedical.news/news/breaking-coronavirus-research-could-echinacea-act-as-a-prophylaxis-against-the-sars-cov-2-coronavirus-more-research-warranted< br />  
Though most SARS-COV-2 infections cause mild-to-moderate COVID-19, a substantial proportion leads to severe disease characterized by vasculitis, coagulopathy, and multi-organ damage that can lead to death. Such advanced disease can be caused by the overproduction of certain cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin -6 (IL-6), and interferon-gamma (IFN-γ).
 
Also although some vaccines protecting against SARS-CoV-2 infection have recently become available, their&nb