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  Oct 15, 2018

Fecal Microbiota Transplantation

The human intestine contains at least 1014 bacteria, with hundreds to thousands of different species, which exist in harmony with their host. The role of this intestinal flora, or microbiota, in maintaining the health of an individual is increasingly being appreciated.

The composition of the microbiota is significantly affected by the use of antibiotics and certain diseases, causing microbial imbalances or “dysbiosis”. Fecal microbiota transplantation (FMT) is the transfer of fecal matter and its associated microbiome from a “healthy” individual to a recipient, to correct the dysbiosis and restore balance.

FMT is not a new concept, and its first mention in the literature was during the 4th century when Ge Hong described the use of fecal suspension by mouth for treatment of severe diarrhea or food poisoning.

The increasing interest in FMT again over the last several decades has to a certain extent paralleled the increasing prevalence of Clostridium difficile infection and the desire to find better treatment options for those suffering from severe or refractory infection.

Why FMT for