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Source: Thailand Medical News  Dec 24, 2019  3 years ago
Researchers from Icahn School Of Medicine On The Way To Finding Treatment To Prevent Hair Loss And Baldness
Researchers from Icahn School Of Medicine On The Way To Finding Treatment To Prevent Hair Loss And Baldness
Source: Thailand Medical News  Dec 24, 2019  3 years ago
Medical researchers from Icahn School Of Medicine, Mount Sinai say a new hair growth discovery might help men keep their locks for a lifetime. The new insight involves a structure lying within the hair follicle.

Lead researcher Dr. Michael Rendl, an associate director of the Black Family Stem Cell Institute at the Icahn School of Medicine at Mount Sinai, in New York City told Thailand Medical News, "Our major discovery is a previously unknown smooth muscle that surrounds hair follicles and is called the dermal sheath."

Dr Rendl explained that in the life cycle of each human hair, a new hair shaft is created by so-called dermal papilla cells. These specialized cells begin at the base of growing hair follicles, but then move slowly upwards toward stem cells that are found at the follicle's tip.

Typically, these stem cells receive signals from the nearby dermal papilla cells "to start the next growth phase and make a new hair shaft, while the previous hair shaft is shed," the researchers explained in a Mount Sinai news release.

The problem is that, sometimes this cell-to-cell partnership gets interrupted. And that could play a role in hair loss.

For a long time, one question that's long puzzled researchers is how the dermal papilla cells travel up towards the stem cells.

Experimenting with animal models, "we found an answer for how this works by discovering that the dermal sheath surrounding growing hair follicles is a smooth muscle, whose function is to contract and push up the hair shaft and pull up the dermal papilla," Dr Rendl said.

Further detailed experiments suggest that human hairs follow a similar mechanism, his team said.

In the hair "destruction" phase of the hair-growth cycle, the dermal sheath contracts, allowing for existing hair strands to fall out. This happens naturally in full heads of hair, but when it occurs too often, baldness can begin to set in.

According to Dr Rendl, this new insight into how the dermal sheath works could re-focus research into hair loss.

Dr Rendli explained, "Blocking the newly discovered muscle and its contraction cannot cure baldness caused by those processes. Instead, blocking contraction and arresting the destruction phase of the cycle has the potential to retain the existing hair shaft that is otherwise lost when a new hair shaft is produced.

Dr Rendl added, "This type of muscle cannot be controlled voluntarily, it is similar to the ones in blood vessels.But we can control it by drugs that can block contraction."

This means that men might someday have a treatment that simply allows them to maintain the head hair they have now, instead of slowly losing it.

Dr Rendl added, "We are excited about the possibility to develop methods for blocking sheath contraction, stopping follicle regression and preventing the loss of the existing hair before a new hair can grow."

A leading dermatologist who knows about hair loss said the findings might offer new hope to follicularly challenged men.
Dr. Michele Green, of Lenox Hill Hospital in New York City commented, "The future of hair loss looks very promising and this study shows that baldness may soon be optional. There have been numerous research efforts into regenerating hair, but this study shows that the dermal sheath can preserve the hair follicle to regenerate new hair growth.”

Dr Green added, besides potentially arresting the hair-growth cycle before its "destruction" phase, tweaking the dermal sheath might also "prevent the hair follicle from going dormant. That's important, because "dormant hair follicles cannot be restored, therefore cannot regenerate hair."

Still, a cure for balding pates isn't around the corner, Rendl stressed.

Dr Rendl added,"There is a longer way to go realistically before blocking contraction of the sheath muscle can be made a reality to halt the hair cycle in the destruction phase. It needs to be proven effective in human hair follicles in the dish first and proven safe after knowing what happens to the arrested follicles long-term. Still, we are excited about exploring this.”

The findings were published Dec. 19 in the journal Science.

Reference : Nicholas Heitman et al. Dermal sheath contraction powers stem cell niche relocation during hair cycle regression, Science (2019). DOI: 10.1126/science.aax9131


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