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Source: Latest Medical News   Dec 04, 2020  3 years, 4 months, 2 weeks, 3 hours, 55 minutes ago

Latest Medical News Reports That Metformin Can Drastically Reduce COVID-19 Mortality Risks In Women

Latest Medical News Reports That Metformin Can Drastically Reduce COVID-19 Mortality Risks In Women
Source: Latest Medical News   Dec 04, 2020  3 years, 4 months, 2 weeks, 3 hours, 55 minutes ago
The latest medical news circulating around is based on a new study by researchers from the University of Minnesota Medical School and UnitedHealth Group-Florida in which it was found that metformin was associated with significantly reduced COVID-19 death risks in women in one of the world's largest observational studies of COVID-19 patients.


 
According to the study, type 2 diabetes and obesity, as states of chronic inflammation, are risk factors for severe COVID-19. Metformin has cytokine-reducing and sex-specific immunomodulatory effects. Our aim was to identify whether metformin reduced COVID-19-related mortality and whether sex-specific interactions exist.
 
In this retrospective cohort analysis, the study team assessed de-identified claims data from UnitedHealth Group (UHG)'s Clinical Discovery Claims Database. Patient data were eligible for inclusion if they were aged 18 years or older; had type 2 diabetes or obesity (defined based on claims); at least 6 months of continuous enrolment in 2019; and admission to hospital for COVID-19 confirmed by PCR, manual chart review by UHG, or reported from the hospital to UHG. The primary outcome was in-hospital mortality from COVID-19. The independent variable of interest was home metformin use, defined as more than 90 days of claims during the year before admission to hospital. Covariates were comorbidities, medications, demographics, and state. Heterogeneity of effect was assessed by sex. For the Cox proportional hazards, censoring was done on the basis of claims made after admission to hospital up to June 7, 2020, with a best outcome approach. Propensity-matched mixed-effects logistic regression was done, stratified by metformin use.
 
It was found that 6256 of the 15 380 individuals with pharmacy claims data from Jan 1 to June 7, 2020 were eligible for inclusion. 3302 (52·8%) of 6256 were women. Metformin use was not associated with significantly decreased mortality in the overall sample of men and women by either Cox proportional hazards stratified model (hazard ratio [HR] 0·887 [95% CI 0·782–1·008]) or propensity matching (odds ratio [OR] 0·912 [95% CI 0·777–1·071], p=0·15).
 
The study findings showed that metformin was associated with decreased mortality in women by Cox proportional hazards (HR 0·785, 95% CI 0·650–0·951) and propensity matching (OR 0·759, 95% CI 0·601–0·960, p=0·021). There was no significant reduction in mortality among men (HR 0·957, 95% CI 0·82–1·14; p=0·689 by Cox proportional hazards).
 
The study team concluded that Metformin was significantly associated with reduced mortality in women with obesity or type 2 diabetes who were admitted to hospital for COVID-19.
 
The research findings were published in the peer reviewed journal: The Lancet Healthy Longevity https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(20)30033-7/fulltext
 
The drug metformin is an established, generic medication for managing blood sugar levels in