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In cases where hairy cell leukemia is suspected, diagnosing the condition is relatively straight forward.
The diagnosis process involves the following steps:
Flow cytometry is also performed to exclude other conditions that present with similar symptoms such as aplastic anemia, myelophthisis and other blood cancers such as atypical chronic lymphocytic leukemia, B-cell prolymphocytic leukemia, hypoplastic myelodysplastic syndrome and idiopathic myelofibrosis.