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Source: Coronavirus Research   Mar 09, 2020  3 years ago
BREAKING! Preprint Research Shows That SARS-CoV-2 Has Third Binding Mode, Making It A Truly Potent Coronavirus That Is In A League Of Its Own
BREAKING! Preprint Research Shows That SARS-CoV-2 Has Third Binding Mode, Making It A Truly Potent Coronavirus That Is In A League Of Its Own
Source: Coronavirus Research   Mar 09, 2020  3 years ago
Coronavirus Research: The first research studies showed that the SARS-Cov-2 coronavirus that causes the Covid-19 disease attaches or binds itself to human cells by using the Angiotensin- converting enzyme-2 (ACE2) receptors. This has been verified by so many studies. (https://link.springer.com/article/10.1007/s00134-020-05985-9) , (https://www.nature.com/articles/s41421-020-0147-1) , (https://www.cell.com/cell/pdf/S0092-8674(20)30229-4.pdf), (https://www.ncbi.nlm.nih.gov/pubmed/32100877)

Then came the shocking revelation that it contains a mutated gene similar to the HIV virus, and is also able to attacks or bind to the human cells through another target called furin. This was verified by two non-peer studies in China and one peer reviewed study in France. This mode of attack also makes it more extremely more potent attributing to the fact as to why it is so easily spread. (https://www.thailandmedical.news/news/breaking-latestcoronavirus-research-reveals-that-the-virus-has-mutated-gene-similar-to-hiv-and-is-1,000-times-more-potent-)

Now a new non-peer reviewed study that was released by the researchers from the University of Cairo, Egypt but of which, there are also two other ongoing similar studies by research lab entities in Europe, one in Germany and another in France almost coming to the same conclusion with their peer-review studies to be released soon, indicating that the spike proteins in the SARS-CoV-2 coronavirus is also able to bind to the GRP78 receptors (Glucose Regulated Protein 78) on human cells. (https://www.researchsquare.com/article/rs-15157/v1)

A genomic researcher and virologist from the Wyss Institute at Harvard University, who wanted to comment under conditions of anonymity said that already when researchers were studying the ACE-2 receptor entry mode, it was discovered that this new coronavirus could utilize not only the protease called TMPRSS2 to enter the cells but at least 8 different other proteases, making things highly difficult when trying to develop inhibitors and drugs. With the advent that it could also use furin as a gateway it made things more complicated. He said that if this pre-print study is confirmed, it would really add a major obstacle to developing proper therapeutics to cure the disease.
The new preprint non-peer reviewed study was conducted by Dr Abdo Elfiky, from the University of Cairo, who is a leading genomic specialists and microbiologists who has published a series on related studies in other peer-reviewed journals with regards to his studies on GRP78 receptors.
The implications of this study is phenomenal as along with the first two modes of entry, it has bearings on how the virus can cause damage and cause complications in the human body, even in residual dormant viral loads. Thailand Medical News will be featuring a few new articles on this in the coming days.
For more latest updates on  coronavirus research, keep on logging to Thailand Medical News


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