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Source: SARS-CoV-2 And Cancer  Mar 30, 2021  3 years, 2 weeks, 4 days, 16 hours, 12 minutes ago

Breaking News! Chinese Researchers Discover circRNAs Encoded By SARS-CoV-2 Virus That Can Cause Cancer! Millions Expected To Get Cancer Eventually!

Breaking News! Chinese Researchers Discover circRNAs Encoded By SARS-CoV-2 Virus That Can Cause Cancer! Millions Expected To Get Cancer Eventually!
Source: SARS-CoV-2 And Cancer  Mar 30, 2021  3 years, 2 weeks, 4 days, 16 hours, 12 minutes ago
SARS-CoV-2 And Cancer: A new study by Chinese researchers from Hunan University has found the presence of thousands of viral proteins known as circRNAs encoded by the SARS-CoV-2 coronavirus with some that have the potential to trigger cellular and genetic reactions that can lead to cancer ultimately.


 
It is already known that the life-threatening coronaviruses MERS-CoV, SARS-CoV-1 and SARS-CoV-2 (SARS-CoV-1/2) have caused and will continue to cause enormous morbidity and mortality to humans.
 
Virus-encoded noncoding RNAs are poorly understood in coronaviruses. Data mining of viral-infection-related RNA-sequencing data has resulted in the identification of 28 754, 720 and 3437 circRNAs encoded by MERS-CoV, SARS-CoV-1 and SARS-CoV-2, respectively.
 
Interestingly MERS-CoV exhibits much more prominent ability to encode circRNAs in all genomic regions than those of SARS-CoV-1/2. Viral circRNAs typically exhibit low expression levels. Moreover, majority of the viral circRNAs exhibit expressions only in the late stage of viral infection.
 
Detailed analysis of the competitive interactions of viral circRNAs, human miRNAs and mRNAs in MERS-CoV infections reveals that viral circRNAs up-regulated genes related to mRNA splicing and processing in the early stage of viral infection, and regulated genes involved in diverse functions including cancer, metabolism, autophagy, viral infection in the late stage of viral infection.
 
Also similar analysis in SARS-CoV-2 infections reveals that its viral circRNAs down-regulated genes associated with metabolic processes of cholesterol, alcohol, fatty acid and up-regulated genes associated with cellular responses to oxidative stress in the late stage of viral infection.
 
A few genes regulated by viral circRNAs from both MERS-CoV and SARS-CoV-2 were enriched in several biological processes such as response to reactive oxygen and centrosome localization.
 
This study provides the first glimpse into viral circRNAs in three deadly coronaviruses and would serve as a valuable resource for further studies of circRNAs in coronaviruses.
 
It also provides a warning about potential cancers that could ultimaltely develop in millions of so called ‘recovered’ COVID-19 patients!
 
The study findings were published in the Oxford Academic peer reviewed journal: Briefings in Bioinformatics.
https://academic.oup.com/bib/article/22/2/1297/6015892
 
To date, the COVID-19 pandemic caused by the SARS-CoV-2 has claimed more than 2.8 million lives. SARS-CoV-2 belongs to the Coronaviridae family, which contains a positive and single-stranded RNA genome. In addition to SARS-CoV-2, researchers have reported the presence of six potentia