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  Sep 28, 2018

How is Alport Syndrome Treated?

There are various treatments that are used to help patients with Alport syndrome to manage their condition. Most of them are used to help reduce and slow down symptoms. The benefits of the treatments are mostly realized when they are implemented early in the patient’s diagnosis with the syndrome.

Dealing with blood pressure

Various medicines that impact the development of kidney symptoms for Alport syndrome act on the renin-angiotensin-aldosterone system in the body, which regulates blood pressure in the body. A class of medicines called angiotensin-converting enzyme (ACE) inhibitors are sometimes used when proteinuria is detected in patients. With the condition, blood pressure can build up in the blood vessels of patients. These particular medicines reduce the pressure by opening up the blood vessels.

Another class of medicine that helps with treatment is angiotensin receptor blockers (ARBs). These are also used to deal with high blood pressure by relaxing the patient’s blood vessels. They do this by blocking the action of angiotensin II. ARBs can sometimes have fewer side effects in patients than ACE inhibitors. Both classes of medicines help to delay the progression to End Stage Renal Disease (ESRD) in patients who have Alport syndrome.



Monitoring protein levels

Doctors can start monitoring possible proteinuria symptoms (abnormal levels of protein in the urine) in children as young as one year of age, who are at risk from the syndrome. They can carry out tests as regularly as once a year in infants who might be prone to reaching ESRD before they reach the age of 30.

Dealing with water retention

If a patient is retaining extra fluid, their doctor may prescribe diuretics to help the kidneys release the extra water in their system as urine. The medical team should also be careful to make sure that too much salt is not excreted.

Keeping cholesterol in check

High cholesterol is also a danger to the patient with Alport syndrome. Statins may also be helpful to the patient in controlling the level of low-density lipo-proteins (LDL) in the body. A high level can be dangerous for the body.

Diet and Lifestyle

Diet can have an impact on how quickly a patient’s health progresses to ESRD. Therefore, there are changes that the patient can implement with advice from a medical expert. The patient should try to reduce the amount