MUST READ! A Mendelian Randomization Study On The Causal Effects Of COVID-19 On Cancer Risk Reveals Shocking Findings!
COVID-19 News - Causal Effects Of COVID-19 On Cancer Risk Apr 17, 2023 2 months ago
COVID-19 News: The world has been grappling with the COVID-19 pandemic for years, and while the immediate dangers are evident, recent scientific discoveries have uncovered a terrifying and unspoken connection between the coronavirus and various types of cancer.
A groundbreaking study using Mendelian randomization (MR) has revealed startling causal associations between COVID-19 and an increased risk of certain cancers, leaving the world to wonder: what hidden consequences of this global health crisis are still left to be discovered?
The study was conducted by researchers from the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China using COVID-19 data sets from the COVID-19 Host Genetics Initiative GWAS meta-analysis round 7 that focusses only on Europe.
COVID-19 has not only affected millions of lives but has also had severe repercussions on cancer diagnosis and treatment. With healthcare systems strained and cancer screening significantly reduced, advanced cancer cases have been on the rise. However, until now, the long-term effects of COVID-19 on cancer risk have remained a mystery.
Thailand Medical News had previously covered various
COVID-19 News coverages about cancer risk as a result of SARS-CoV-2 infections.
https://www.thailandmedical.news/news/understanding-the-link-between-covid-19-and-cancer-the-role-of-the-slc6a20-gene
https://www.thailandmedical.news/news/cd147-and-cyclophilin-a-cypa-play-key-roles-in-covid-19-severity,-cancer-progression-and-chemotherapy-resistance-in-cancer-patients-with-covid-19
https://www.thailandmedical.news/news/sars-cov-2-and-cancer-increased-neuropilin-1-expression-as-a-result-of-covid-19-can-lead-to-progression-of-primary-brain-tumors-besides-neurological-i
https://www.thailandmedical.news/news/covid-19-news-scientists-warn-that-sars-cov-2-infections-can-lead-to-rapid-progression-of-cervical-intraepithelial-neoplasia-to-cervix-cancers
https://www.thailandmedical.news/news/covid-19-news-will-sars-cov-2-infections-ultimately-lead-to-an-increased-incidence-of-head-and-neck-cancers
ons-lead-to-increased-risk-of-breast-cancer,-recurrence-of-breast-cancer-and-also-breast-cancer-metastasis">https://www.thailandmedical.news/news/breaking-covid-19-news-sars-cov-2-infections-lead-to-increased-risk-of-breast-cancer,-recurrence-of-breast-cancer-and-also-breast-cancer-metastasis
https://www.thailandmedical.news/news/covid-19-news-can-sars-cov-2-cause-reactivation-of-the-latent-sexually-transmitted-htlv-1-virus-that-causes-t-cell-leukemia-lymphoma-atl
https://www.thailandmedical.news/news/breaking-covid-19-news-sars-cov-2-infections-lead-to-cellular-m6a-rna-methylation-loss-in-host-cells-possible-implications-for-cancer-and-other-issues
https://www.thailandmedical.news/news/breaking-researchers-from-brazil-warn-sars-cov-2-induced-immunological-dysregulation-can-increase-the-risk-of-skin-and-blood-cancer-relapses
https://www.thailandmedical.news/news/spanish-study-discovers-that-sars-cov-2-infections-leads-to-downregulation-of-p53-a-critical-cancer-protective-gene
https://www.thailandmedical.news/news/breaking-study-finds-that-upregulated-interleukin-6-drives-development-of-rare-liver-cancers-covid-19-infections-causes-elevated-il-6-levels-in-many
https://www.thailandmedical.news/news/breaking-study-finds-that-cancer-causing-genes-are-upregulated-in-sars-cov-2-infected-individuals
https://www.thailandmedical.news/news/great-news-study-shows-that-sars-cov-2-protein-nsp13-is-able-to-cause-dna-damage-and-dysregulate-tumor-suppressor-gene-p53,-increasing-cancer-risk
https://www.thailandmedical.news/news/breaking-sars-cov-2-activates-epidermal-growth-factor-receptor-mediated-signaling,-inducing-survivin-expression-which-assists-in-cancer-progression
https://www.thailandmedical.news/news/post-covid-19-individuals-advised-to-take-probiotics-as-study-shows-sars-cov-2-induced-gut-microbiome-dysbiosis-increases-risk-for-colorectal-cancer
https://www.thailandmedical.news/news/breaking-sars-cov-2-infection-induces-increase-of-gp73-that-causes-dysglycaemia-increased-gp73-could-also-imply-future-liver-disease-and-liver-cancer
https://www.thailandmedical.news/news/breaking-new-international-study-warns-that-sars-cov-2-infections-will-lead-to-cancers-especially-colorectal-cancers-due-to-disruption-in-autophagy
https://www.thailandmedical.news/news/breaking-news-chinese-researchers-discover-circrnas-encoded-by-sars-cov-2-virus-that-can-cause-cancer-millions-expected-to-get-cancer-eventually
https://www.thailandmedical.news/news/must-read-covid-19-questions-can-the-sars-cov-2-coronavirus-ultimately-also-cause-cancer
This new eye-opening study has finally shed light on the causal links between three types of COVID-19 exposures (critically ill COVID-19, hospitalized COVID-19, and SARS-CoV-2 infection) and the risk of 33 different types of cancers. The results are nothing short of alarming.
The study findings indicate that genetic predispositions to critically ill COVID-19 are linked to an increased risk for HER2-positive breast cancer, esophageal cancer, colorectal cancer, stomach cancer, and colon cancer. Furthermore, genetic predispositions to hospitalized COVID-19 are linked to an increased risk for HER2-positive breast cancer, esophageal cancer, and stomach cancer. Lastly, genetic predispositions to SARS-CoV-2 infection are linked to an increased risk for stomach cancer, but a decreased risk for head and neck cancer.
The more severe the COVID-19 exposure, the higher the likelihood of developing more types of cancer. However, it's important to note that the risk of cancer is higher for mild COVID-19 cases than for severe cases. This groundbreaking discovery implies that even after the pandemic subsides, the long-term effects of COVID-19 on cancer risk could linger, affecting the health of millions of people.
One particularly concerning finding is that all three types of COVID-19 exposures are risk factors for gastric cancer. This could be due to the long-term replication of SARS-CoV-2 in the gastrointestinal tract. Though primarily a respiratory virus, COVID-19 is known to cause gastrointestinal symptoms, and the virus can persist in the gastrointestinal tract even after symptoms disappear.
The study also discovered that critically ill and hospitalized COVID-19 exposures were risk factors for HER2-positive breast cancer but not for other breast cancer subtypes. This could be linked to the high expression level of ACE2 (angiotensin-converting enzyme 2) on HER2-positive breast cancer cells.
On the other hand, the decreased risk of head and neck cancer in individuals with a genetic predisposition to SARS-CoV-2 infection might be due to the low expression of TMPRSS2 (trans-membrane protease serine 2), a SARS-CoV-2 internalization protease, in head and neck cancer cells.
While the study presents significant findings, some limitations must be noted. The study primarily focuses on individuals of European descent, which could limit its applicability to other populations. Additionally, other confounding factors could still be present, and the study only assesses genetic predispositions to COVID-19 and cancer.
Despite these limitations, the study's results are of vital importance for public health policies and the long-term management of COVID-19 survivors. It is crucial to monitor the risk of gastrointestinal and HER2-positive breast cancer in COVID-19 patients, particularly those who experienced severe illness. Comprehensive health follow-up systems must be established to strengthen cancer screening and early detection in COVID-19 survivors to improve their prognosis and overall well- being.
The study employs Mendelian randomization (MR), a cutting-edge epidemiological method that is less prone to confounding and reverse causation than traditional observational studies.
The findings of this study are alarming, as they suggest that the COVID-19 pandemic may have far-reaching and long-lasting effects on public health. With millions of people worldwide affected by the virus, the need for comprehensive health monitoring and cancer screening for COVID-19 patients has never been more urgent.
One potential explanation for the link between COVID-19 and cancer risk lies in the fact that SARS-CoV-2, the virus responsible for COVID-19, is a type of RNA virus zoonosis. Previous studies have found that other RNA virus zoonoses, such as bovine leukemia virus, are linked to cancer. In fact, roughly 12% of cancers are associated with cancer viruses.
Three primary mechanisms through which cancer viruses can drive carcinogenic processes include encoding oncogenic viral proteins, causing chronic inflammation, and causing genotoxic damage. It has been suggested that SARS-CoV-2 might drive carcinogenesis by inducing oxidative stress, genomic instability, and degradation of the tumor suppressor gene P53.
In conclusion, this groundbreaking study has shed light on a previously unknown link between COVID-19 and cancer risk. It is crucial for public health officials, medical professionals, and policymakers to take these findings into account when developing strategies to manage the long-term effects of the COVID-19 pandemic. Strengthening cancer screening programs and conducting further research into the underlying mechanisms linking COVID-19 to cancer are essential steps in protecting the health and well-being of millions of people worldwide.
The study findings were published in the peer reviewed Journal of Medical Virology.
https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28722
Please note that this study review has been uploaded on 17th April 2023 at 2257 hrs Sydney Time as readers can monitor a particular French garbage on twitter whose body is in state of generating cancer cells around his prostate glands, pancreas, gastrointestinal tract and liver as the garbage likes to access our site for review of studies done by us and then simply post about the studies without crediting ... the garbage has been doing this for a while now. His followers must also be garbage and hopefully will also meet the same end as him! His twitter handle is @ejustin46
For the latest
COVID-19 News, keep on logging to Thailand Medical News.
Share
Tweet
Share
